代謝症候群(metabolic syndrome,MS)是指在一個人身上出現多重代謝異常,增加心血管疾病的發生率與死亡率。本研究目的為了解代謝症候群與健康受試者血漿抗氧化維生素(輔酶Q10、維生素A及維生素E)濃度與氧化壓力指標(丙二醛,malondialdehyde,MDA)、抗氧化酵素活性﹝過氧化氫酶(catalase,CAT)、超氧歧化酶(superoxide dismutase,SOD)及麩胱甘肽過氧化酶(glutathione peroxidase,GPx)﹞之相關性。MS之判定依據行政院衛生署國民健康局(2007)公布之判定標準(MS組,n = 72)。健康受試者經體檢資料血液生化值於正常範圍內,做為non - MS組(n = 105)。測量受試者血漿輔酶Q10、維生素A、維生素E、血脂質、MDA及抗氧化酵素活性。結果顯示MS組之血漿輔酶Q10及維生素E濃度顯著高於non - MS組;經三酸甘油酯校正後,血漿輔酶Q10及維生素E濃度則無顯著差異,但MS組之血漿維生素A濃度顯著低於non - MS組。MS組之抗氧化酵素活性皆顯著低於non - MS組;但MDA濃度兩組間無顯著差異。受試者之輔酶Q10濃度與SOD活性;維生素A及E濃度與GPx活性有顯著之正相關。本研究認為MS患者可能承受較高之氧化壓力,使抗氧化酵素及維生素A濃度有降低的情形。未來研究須進一步追蹤MS患者,其抗氧化維生素濃度是否隨體內代謝失衡的時間越久而有所改變。
Metabolic syndrome (MS) represents a cluster of physiological and anthropometric abnormalities. The purpose of this study was to investigate the relationships of coenzyme Q10, vitamin A and E, and antioxidant enzymes activities in subjects with MS. Subjects in the case group (n = 72) were according to the criteria for MS, defined by the Taiwan Bureau of Health Promotion, Department of Health (2007). The control group (n = 105) was comprised of healthy individuals with normal blood biochemical values. Plasma coenzyme Q10, vitamin A and E concentrations, lipid profiles, malondialdehyde (MDA) level, and antioxidant enzymes activities [catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx)] in Red blood cell (RBC) were measured. Subjects with MS had significantly higher concentrations of plasma coenzyme Q10 and vitamin E than those in the control group, but these differences disappeared after normalized for triglyceride level. The ratio of vitamin A to triglyceride and antioxidant enzymes activities were significantly lower in the case group compared with the control group. There was a significantly positive correlations between the levels of coenzyme Q10 and SOD (p < 0.01); vitamin A and GPx (p = 0.05); and vitamin E and GPx (p = 0.04) after adjusting for the potential confounders of MS. Subjects suffering from MS may be under a higher oxidative stress, resulting in low levels of antioxidant enzymes activities and vitamin A. Further studies are needed to evaluate antioxidant vitamins status in patients with long-term chronic MS.