COPD病患及正常人維生素C.維生素E血漿濃度及攝取量比較:與飲食型態的相關性

Comparison of plasma and intake levels of vitamin C and vitamin E in COPD patients and healthy people: the correlation with diet pattern

陳珮瑩(Pei-Ying Chen)

指導教授 ： 曾博修

中山醫學大學/醫學院/生化暨生物科技研究所/碩士(2007年)

https://doi.org/10.6834/CSMU.2007.00135

摘要

慢性阻塞性肺病(COPD)是一個主要的全球性健康問題，它的衝擊繼續增長。有證據證實大量的攝取抗氧化營養素(如維生素C、E)可保護肺功能，但是在台灣COPD病患未被證實。此項研究目的為探討確定COPD病患維生素C、E的血漿濃度及飲食攝取量都比健康人低，且台灣COPD病患會因病情影響維生素C、E攝取。受試者中有32名COPD病患，其FEV1％ < 80％，FEV1/FVC < 0.7，另有43名(年齡>=60歲)肺功能正常的健康人。首先收集血漿維生素C、E，白血球內生性及H2O2誘發處理的DNA傷害。利用食物頻率問卷及24小時回憶，評估得到膳食攝取的維生素C、E量。結果得知COPD病患膳食中攝取的維生素C、E量比健康人低，但COPD病患內生性及H2O2誘發處理的DNA傷害卻比健康人高。若將2個族群混合，我們發現COPD病患總蔬果攝取量比健康者低，尤其是冷性蔬果。COPD病患冷性蔬果的攝取頻率與膳食中維生素C、E量是正相關。結果顯示台灣COPD病患血漿和膳食中的維生素C、E是低於健康人。

關鍵字

慢性阻塞性肺病 ； 維生素C ； 維生素E ； 24小時飲食回憶法 ； 食物頻率問卷

並列摘要

Chronic obstructive pulmonary disease (COPD) is a major health problem across the world and its impacts continue to grow . There are increasing evidences that individuals with a high intake of antioxidative nutrients such as vitamin C and vitamin E tend to maintain better lung function. However, little has been known about COPD patients in Taiwan. The purposes of this study were to determine whether COPD patients have lower plasma and intake levels of vitamin C or vitamin E than healthy people, and whether the diet patterns of COPD patients affect their intake of vitamin C or vitamin E in Taiwan . Thirty-two COPD patients, who met satisfied the criteria with forced expiratory volume in 1 second (FEV1) % predicted less than 80% and a ratio of FEV1 to forced vital capacity (FVC) less than 0.7, were recruited in this study; whereas, forty-three healthy people, who are ≧ 60 years of age and with normal lung function, were recruited. Fasting venous blood were collected to measure the level of vitamin C, vitamin E and the endogenous and H2O2-induced DNA damage in white blood cells (WBC). Using food frequency questionnaire and 24-hour dietary recall, we assessed the dietary intake of vitamin C and vitamin E. The results showed that the mean plasma and intake levels of vitamin C and vitamin E of COPD patients were significantly lower than that of healthy people. The endogenous and H2O2-induced WBC DNA damage of COPD patients were significantly higher than that of healthy people. Pooling the data of 2 groups, we found the increase of H2O2-induced WBC DNA damage after adjusted sex, age, BMI, carbohydrate and protein (r = -0.333, p = 0.011).In addition, the sum of vegetables and fruits intake frequency of COPD patients were significantly lower than healthy people, especially in cooling vegetables and fruits. In COPD patients, the intake frequency of cooling vegetables plus fruits was positively correlated with the intake of diet vitamin C, whereas the intake frequency of all vegetables plus fruits had the strongest correlation with dietary intake of vitamin E. In conclusion, COPD patients have low plasma and intake levels of vitamin C and vitamin E than healthy people in Taiwan. The diet pattern may affect the dietary intake of vitamin C and vitamin E .

並列關鍵字

COPD ； vitamin C ； vitamin E ； 24-hours dietary eecall ； food frequency questionnaire

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