聚氧乙烯/銀/二氧化鈦奈米纖維膜之製作與抗菌性之研究

The Fabrication and Antibacterial Activity of PEO/ Ag/ TiO2 Nano-fibrous Membrane

白倩榕(Chien-Jung Pai)

指導教授 ： 鄧道興 ； 鄭國彬

國立臺北科技大學/工程學院/有機高分子研究所/碩士(2010年)

https://doi.org/10.6841/NTUT.2010.00077

摘要

聚氧乙烯為一種白色無臭無汙染之綠色材料，其環境親和性佳，並擁有降解徹底與使用安全方便等水溶性薄膜之特性，使聚氧乙烯受到世界許多發展國家廣泛重視，成為近年來備受重視之高分子材料。聚氧化乙烯可溶於毒性低之有機溶劑乙醇中，形成高分子溶液，利用靜電紡絲技術製備具有奈米纖維結構之薄膜。
本研究第一階段在PEO高分子溶液中添加不同比例（4wt%, 6wt%, 8wt%, 10wt%）之奈米二氧化鈦粉體製得PEO/ TiO2纖維複合薄膜，以SEM觀察纖維平均細度約在635nm~867nm。以EDS做元素分析，圖譜中出現Ti的元素特徵峰。以ATR-FTIR做表面特徵官能基分析，發現添加TiO2後可明顯發現隨著其添加量的增加特徵峰有增強趨勢。並且利用DMA做機械性質分析，發現在奈米二氧化鈦粉體重量百分比為4wt%時機械性質最佳。DSC與TGA熱性質分析結果，隨著TiO2粉體添加量的提升，熱裂解溫度也隨之降低，但是對玻璃轉化溫度、熔點並未造成顯著的影響。以UV/ Visable 測試其抗紫外線效果，發現隨著TiO2的增加其抗紫外線有增強之趨勢。而在抗菌效果方面，隨著TiO2的增加，抑制效果也有增加的趨勢。
第二階段則是在不同TiO2重量百分比（4wt%, 6wt%, 8wt%, 10wt%）之PEO/ TiO2高分子溶液中加入奈米銀水溶液，並以相同參數靜電紡絲製成PEO/ Ag/ TiO2奈米纖維薄膜，以SEM觀察纖維平均細度約在425nm~529nm。以EDS作元素分析，圖譜中出現Ag元素之特徵峰。以ATR-FTIR對其做表面特徵官能基分析，發現並沒有額外之特徵峰，推斷奈米銀水溶液之加入為物理混參並無化學鍵結。並利用DMA做機械性質分析，發現仍是TiO2添加量為4wt%時機械性質最佳，並且發現加入奈米銀之奈米纖維膜之機械性質皆有提升。DSC與TGA熱性質分析結果，發現加入奈米銀之奈米纖維膜之熱裂解溫度皆有升高，而熱焓則是有減少的趨勢。對金黃色葡萄球菌之抑菌能力測試結果發現奈米銀的加入使其抑菌率提高至>99%，並達到滅菌的效果。期望能應用在紫外線與阻隔材及醫療敷材等。

關鍵字

聚氧乙烯 ； 二氧化鈦 ； 銀 ； 靜電紡絲 ； 奈米纖維 ； 抗紫外線 ； 抗菌

並列摘要

Poly(ethylene oxide) (PEO) is a green material of white-color, odorless and pollution-free. With the Characteristic of environmental compatibility, the complete degradation, water-solubility and the safety and convenience of usage, PEO has been attentioned and studied by the whole world and becoming a high value polymer material. PEO is soluble in organic solvent with low toxicity like ethanol to form polymer solution. and afterward, it could be fabricated nano-fibrous membranes by electrospinning.
The first step of this experiment was to prepare PEO/ TiO2 composite nano fibrous membranes with diffirent weight percentage of nano titanium dioxide powders by electrospinning. The morphology of fibrous membranes was investigated by the SEM and the results showed that its average diameters were in the range of 635nm~867nm. The EDS results showed the featuring peak of Ti. The spectra of FTIR showed the Ti-O-C featuring peak was rised with the increasing of TiO2 concentration. The membranes with 4 wt% of TiO2 had the best mechanical properties. As to obtain the thermal properties of PEO/ TiO2 membranes, the decomposition temperature of membranes and its relationship to the weight loss were examined by TGA. In addition, the variation in Tm and Tc were analyzed with DSC. The Tm and Tc of PEO polymer had little doing with the addition of TiO2 which was taken account of the low thermal collapse temperature. Furthermore, the characteristics of inhibition of bacteria growth and UV cut of PEO fibrous membranes would be achieved by adding TiO2. From the experimental results, it showed that both were rised with the increasing of TiO2 concentration.
The second step of this experiment was to add nano silver solution into PEO/ TiO2 polymer solution to produce PEO/ Ag/ TiO2 nano-fibrous membranes by electrospinning. The results of SEM showed that its average diameters were in the range of 425nm~530nm, and showed the featuring peak of Ag in the results of EDS. From the data of ATR-FTIR test, it was concluded that neither new groups were made nor phenomenon of displacement was happened. Also, the results of DMA showed that the mechanical properties of membranes were all rised by adding Ag. The thermal properties were analyzed by DSC and TGA which showed the rise of Td and the decline of enthalpy with Ag nano particle. As for the effect of antibacterial, it showed higher than 99% of inhibiting in the growth of staphylococcus aureus and klemsiella pneumoniae.

並列關鍵字

PEO ； TiO2 ； Ag ； Electrospinning ； Nano-fibrous ； Antibiotic

參考文獻

32. 黃宣諭，以電氣紡絲法製備具方向性纖維之管狀結構，碩士，國立交通大學機械工程學系，新竹，2009。

80. 陳世衛，氧化鋅高壓相變之研究，碩士，國立新竹師範學院自然科學教育學系，台北，2005。

37. 許朝翔，利用恆溫滴定微卡計探討聚乙二醇抗蛋白質吸附之作用機制，國立中央大學，碩士論文，2007。

69. 曾俊豪，探討銀奈米粒子於改質之聚丙烯纖維表面形成機制，碩士，國立成功大學化學工程研究所，台南，2005。

1. 洪崇豪，以電紡絲製備彈性奈米SBS纖維膜，碩士，國立成功大學化學工程系，台南，2004。