不銹鋼表面功能化處理之特性研究

Characteristic Research of Functional Modification on Stainless Steel

陳思翰(Chi-Han Chen)

指導教授 ： 林哲堂

共同指導教授 ： 歐耿良

臺北醫學大學/口腔醫學院/牙醫學系碩博士班/碩士(2009年)

https://doi.org/10.6831/TMU.2009.00002

摘要

316 L不銹鋼經由表面處理後，經血液相容性實驗證實不銹鋼經表面處理後對於血塊的形成有極大的影響。有諸多學者對於人造之生醫材料研究顯示：生醫材料表面必須先有血液中之蛋白質吸收於材料表面後，才可能會有後續的一些細胞反應進而達到所追求之生物相容性。血液中有數百種蛋白質，其中以血漿蛋白為最多，而血漿蛋白會使凝血的時間拉長，使血塊延後產生。 對於一個牙科植體手術的區域來說，血塊的存在與骨頭生長的是植體手術成功與否的關鍵，骨頭能夠生長才能更進一步促進植體與骨頭的骨結合，即所謂之骨整合。
本次研究將316 L不銹鋼經由表面處理後，於不同電壓及不同處理時間為參數，嘗試著去與血液中所存在的纖維蛋白及免疫蛋白相容，經由一系列的血液實驗來證實處理過的316 L不銹鋼不引起過多的細胞沾附及良好的血液相容性，可用做為最好的過渡期植體骨釘。

關鍵字

316 L不銹鋼 ； 表面功能化處理 ； 血液相容性

並列摘要

316L stainless steel treated with the electrochemistry greatly influenced the rate of blood coagulation, which had been proven by series of blood compatibility tests. Previous studies have shown that the protein adsorption is the key to further induce the interactions between cells and material surfaces. In the blood, the albumin is the most abundant protein, the adsorption of the albumin tends to prolong the formation of the blood clot. However, the presence of the blood clot in the dental implant site is crucial in order for the bone formation to initiate, which leads to the ultimate goal, “ osseointegration ”.
In the present research, we treated the 316L stainless steel with various voltages and charged times of positive charge. We then put these samples through a series of blood test, in order to find the best hemocompatible sample for interim implant screw.

並列關鍵字

316L stainless steel, electrochemistry ； blood compatibility

參考文獻

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