改質透明質酸對水凝膠的保濕性與機械性質影響

Effect of the Modified Hyaluronic Acid on the Water Retention and Mechanical Properties of Poly(2-hydroxyethyl methacrylate) Hydrogel

顏文德(Wen-De Yan)

指導教授 ： 洪信國

元智大學/工程學院/化學工程與材料科學學系/碩士(2009年)

摘要

本研究目的在於改質透明質酸（hyaluronic acid，HA），使其具反應性可聚合交聯，探討以此改質之透明質酸製成水凝膠材料之水吸脫附與機械性質。結果證實透明質酸有效鍵結不飽和單體為改質透明質酸MHA，此MHA可自行光聚合並且不溶於水，添加於Hydroxyethyl Methacrylate (HEMA)，能提高水凝膠吸水性、保濕性與機械強度。添加改質量不同MHA，改質量越多MHA，自由水減少，半結合水量增加，加入越多的MHA，自由水與半結合水量增加，D（Diffusion coefficient）變小，水分揮發量減少。

關鍵字

hyaluronic acid ； poly(2-hydroxyethyl methacrylate) ； diffusion coefficient ； 保濕性 ； 水凝膠 ； 自由水 ； 鍵結水

並列摘要

The effects of the modified hyaluronic acid on the bounded water content, water retention, water content, and mechanical properties of poly(2-hydroxyethyl methacrylate) hydrogel are studied using differential scanning calorimetry (DSC), Fourier transformed infrared spectroscopy (FTIR), water evaporation measurement, and mechanical tester. From FTIR analyses, it is obtained that the hyaluronic acid can be effectively grafted with the reactive monomer by the reaction conditions used. The modified hyaluronic acid is curable and drastically increases the water content and improves the water retention and mechanical properties of the hydrogel. The results of DSC indicate that the semibounded water and free water contents increase with the content of the modified hyaluronic acid. The water diffusion coefficient of the hydrogel with the modified hyaluronic acid is five times smaller than that of the unadded hydrogel. The use of a small amount of the modified hyaluronic acid would significantly improve the water retention of the hydrogel.

並列關鍵字

poly(2-hydroxyethyl methacrylate) ； hydrogel ； hyaluronic acid ； water retention ； bounded water ； diffusion coefficient

參考文獻

【1】O. Wichterle, D. Lim, “Hydrophilic gels in biologic use”, Nature , 185, 117 (1960)

【4】I. C. Kwon, Y. H. Bae and S. K. Kim., “Electrically erodible polymer gel for controlled release of drugs.” , Nature, 354, 291 (1991)

【5】S. Kitanto, K. Katoka, Y. Koyaman, T. Okano and Y. Sakurai., “Glucose- responsive complex formation between poly (vinyl alcohol) and poly (N-vinyl-2-pyrrolidone) with pendent phenylboronic acid moeties.”, Makromol Chem Rapid Commun, 12, 227 (1991)

【6】Barenberg S. A., “Abridgel Report of the Committee to Survey the

【7】Lin F. H., Chen T.M., Chen K.S., et al. ,“An animal study of a noveal tri-layer wound dressing material-non-woven fabric grafted with N-isopropylacrylamide and gelatin”, Materials Chemical and Physics, 64, 189-195 (2000)