探討重鬱症患者在誘發憂鬱與快樂情緒下之前額葉α波不對稱現象

Frontal alpha asymmetry during evoked depression and happiness in patients with major depressive disorder

陳毓婷(Yu-Ting Chen)

指導教授 ： 林宜美

高雄醫學大學/人文社會科學院/心理學系碩士班/碩士(2015年)

https://doi.org/10.6832/KMU.2015.00141

摘要

目的：過去研究證實休息狀態之左右大腦前額葉α波不對稱現象(alpha asymmetry)可作為重鬱症(major depression disorder, MDD)之特質標誌(trait marker)，少有研究探討重鬱症患者與健康控制組在不同情緒狀態下之腦波。本研究目的為檢驗重鬱症患者在經歷憂鬱及快樂情緒誘發時之大腦前額葉α波不對稱現象，以及憂鬱、主觀情緒分數與各實驗階段α波不對稱現象之關係，以檢驗重鬱症之特質與情境標誌(state marker)。
方法：採二因子混合實驗設計與對抗平衡設計，納入38名重鬱症患者(平均年齡36.21 ± 13.56歲)與48名健康控制組(平均年齡36.44 ± 11.55歲)，分別經歷休息狀態、憂鬱回憶期與快樂回憶期，並測量19頻道腦波，分析左右大腦前額葉(F3與F4)α波之平均功率，再換算成α波不對稱指標(A2)。所有參與者均填寫貝克憂鬱量表、憂鬱及快樂情緒評估量表等，以評估憂鬱、主觀情緒分數與各實驗階段α波不對稱現象之關係。
結果：所有參與者之憂鬱總分與認知型憂鬱和基準期之A2指標具顯著負相關，且憂鬱總分可有效預測基準期之A2指標。重鬱組之A2指標在所有實驗階段皆低於控制組之趨勢，達邊緣顯著(p = .05)。重鬱組在回憶期之前、當下以及之後的主觀情緒分數，與經歷情緒誘發(憂鬱、快樂回憶期)時的A2指標皆無顯著相關。
結論：本研究結果支持前額葉α波不對稱現象為重鬱症患者之特質標誌，但無法支持重鬱症患者在經歷憂鬱與快樂情緒誘發時，前額葉α波不對稱現象之情境標誌。

關鍵字

重鬱症 ； 額葉α波不對稱 ； 腦波

並列摘要

Background: Previous studies indicated that resting α asymmetry of the left and right frontal is a trait marker for patients with major depressive disorder (MDD), but few studies explore the electroencephalogram (EEG) under different emotional states between patients with MDD and healthy controls. The purpose of this study is to explore the frontal α asymmetry during evoked depressive and happiness situations, as well as the relationships between depression, subjective emotional scores and the frontal α asymmetry to examine the trait and state markers of MDD.
Methods: Two-factor mixed and counterbalanced design was applied in this study. Thirty-eight patients with MDD (mean age 36.21 ± 13.56 years) and forty-eight healthy controls (mean age 36.44 ± 11.55 years) were recruited. EEG data were measured by 19 channel EEG equipment under resting baseline, depressive-induction and happiness-induction stages; the left and right frontal (F3 and F4) α power were analyzed as asymmetry index (A2). All participants filled out Beck Depression Inventory-II (BDI-II) and depression and happy mood rating scale.
Results: Depression score and cognitive depression of BDI-II were negative correlated with baseline A2 in all participants, as well as depression score of BDI-II could predict baseline A2. MDD group tended to have lower left frontal activation under all experimental stages than control group (p = .05). There were no significant corrections between mood rating scale before, during and after mood-induction stage (happiness and depression) and A2 among patients with MDD.
Conclusion: This study supports that frontal α asymmetry is a trait marker for patients with MDD, but do not supports that frontal α asymmetry as a state marker during happiness and depression-induction situation.

並列關鍵字

major depressive disorder ； frontal α asymmetry ； electroencephalogram

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