以獨立成份分析法探討拉普拉斯電位圖

The study of Laplacian potential mapping using independent component analysis

林昀融(Yun-Rong Lin)

指導教授 ： 徐良育

中原大學/工學院/醫學工程研究所/碩士(2006年)

https://doi.org/10.6840/CYCU.2006.00457

摘要

心房纖維性顫動(atrial fibrillation,AF)發生時訊號是非常紊亂的，無法直接由拉普拉斯電位圖中觀察出活化的位置與電位傳遞的路徑。
本研究使用獨立成份分析法對正常竇性與心房纖維性顫動的拉普拉斯電位圖進行獨立成份分析，找出心房活化區域並探討心臟活化時電氣傳導路徑，同時比較活化次數與活化區塊數目在施打抗心律不整藥物Procainamide後與施打藥物前之變化。
在實驗方面，將開胸狗以電刺激誘發AF，並施打Procainamide使AF停止，以侵入式15×8的電極陣列擷取訊號，經由拉普拉斯電位轉換後進行空間獨立成份拆解。由結果發現心房纖維性顫動時的活化時間序列不像正常竇性節律時只有一個主要的活化訊號，而是多次的活化，序列與序列間的相似度亦不大，這也是造成拉普拉斯電位圖如此紊亂的主要原因。
在施打Procainamide前後的比較中，施打藥物後活化間期比施打藥物前平均增加了56.10 %。活化次數從2.48±0.31次下降為1.29±0.19次，活化區塊數目由8.96±0.52個減少為6.41±1.28個。驗證了心房纖維性顫動發生時，心房周圍會同時出現多個活化碎小波同步活化，而在施打抗心律不整藥物後，活化碎小波的數量會減少，活化區塊的數目比打藥前的數目少。
本研究透過獨立成份分析法把紊亂的心房纖維性顫動時的活化區域顯示出來，探討拉普拉斯電位的走向。並驗證了心房纖維性顫動在施打抗心律不整藥物前、後活化次數與活化區塊數目的差異性。

關鍵字

心房纖維性顫動 ； 獨立成份分析法 ； 拉普拉斯電位圖

並列摘要

The activation position and potential conduction pathway cannot be directly observed by Laplacian map during atrial fibrillation (AF).
This study analyzed normal sinus rhythm (NSR) and AF using Laplacian map and independent component analysis (ICA) in order to find out the activation area of atriums and delve the potential conduction pathway. Additionally, we compared the changes in activation times and activation block numbers before the infusion of anti-arrhythmia drug, Procainamide, with those after the infusion.
The result revealed that the time courses of AF had, unlike the time courses of NSR with only one major activation, more than one activations. Moreover, the multiple activations in time courses of AF and low correlation between time courses were the major reasons for the chaos of Lplacian map. Comparing before Procainamide infusion the activation durations with those after Procainamide infusion increased 56.10% on average. The activation times were decreased from 2.48±0.31 to 1.29±0.19, and the activation block numbers were decreased from 8.96±0.52 to 6.41±1.28. The result proofed that when atrial fibrillation occurs, there are many wavelets activated spontaneously around the periphery of atrium. After Procainamide infusion , the numbers of wavelet and the numbers of activation block decreased.
This study indicated that the activation area can be emphasized using the ICA algorithm , and the result verified that there are differences between before and after Procainamide infusion.

並列關鍵字

atrial fibrillation(AF) ； Laplacian map ； independent component analysis(ICA)

參考文獻

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