- 學位論文
以皮膚模型評估藥膏對紫外光穿透量的影響
Evaluating the effect of medication on the UV transmission by using a skin model
摘要
乾癬(Psoriasis)是非傳染性、長期性、不斷復發、皮膚外觀呈現 鱗片狀的銀屑和紅腫的現象。目前乾癬是一種無法根治的疾病，僅能 靠治療控制住病情。因為窄頻UVB光照療法和PUVA光化學療法的優 點為病灶復發時間較慢，所以是一種日益普遍的乾癬療法。 紫外光劑量進入皮膚組織的多寡是由藥膏的吸收係數和皮膚表 面的散射係數決定。為了解紫外光穿透藥膏的情形，本研究製造具有 皮膚紋路的壓克力模型，模擬皮膚表面的光學散射性質。研究結果顯 示當塗抹少量半透明的藥膏能夠增加紫外光的穿透度，這是因為藉由 藥膏與皮膚的折射係數互相匹配，造成皮膚表面散射減少。而當塗抹 多量的藥膏時，紫外光的穿透量會隨藥膏的吸收度而減少。 藉由具有皮膚表面形狀的模型可準確地估計紫外光劑量。而在光 照治療中，應該小心地控制塗抹藥膏的數量才可以增加紫外光的穿透 量。
並列摘要
Psoriasis is a non-contagious, chronic, and recurrent skin disorder which appears as inflamed lesions and is covered with silvery scale. Up to now, psoriasis still cannot be completely cured, but can only be controlled by treatment. Narrow band ultraviolet-B phototherapy and psoralen with ultraviolet-A photochemotherapy have become popular treatment of psoriasis because of their long recurrent period. The dose of ultraviolet entering skin tissue is determined by the absorption of medication and the scattering on skin surface. In order to measure ultraviolet transmission through applied medication, an acrylic skin model was made in this study to mimic the optical scattering property of skin surface. The results show that ultraviolet transmission increases only when a small amount of translucent medication is applied. This is due to the reduction of surface scattering by matching the refraction index between skin and medication. When more medication is applied, the ultraviolet transmission decreases again because of the absorption by medication. By using the model with skin surface profile, the ultraviolet dose can be more accurately estimated. The amount of medication to increase the ultraviolet transmission in phototherapy should be carefully controlled.
參考文獻
延伸閱讀
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