- 學位論文
利用圓二色及核磁共振光譜技術研究體抑素-28在SDS微胞中之構型
The interaction of somatostatin-28 with SDS micelle studied by circular dichroism and nuclear magnetic resonance spectroscopy
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摘要
體抑素-28(SRIF-28)由二十八個胺基酸所組成之環狀多肽鏈，SRIF-28為體抑素-14(SRIF-14)在N-端延伸一直鏈片段之先驅物，由體抑素原經蛋白酶水解作用切斷胜肽鍵而得，一級結構為：H-Ser1-Ala2-Asn3-Ser4-Asn5-Pro6-Ala7- Met8-Ala9-Pro10-Arg11-Glu12-Arg13-Lys14-Ala15-Gly16-c[Cys17-Lys18-Asn19-Phe20-Phe21-Trp22-Lys23-Thr24-Phe25-Thr26-Ser27-Cys28]-OH。體抑素原中鹼性胺基酸(Arg)殘基受到蛋白酶水解生成SRIF-28，而迴路構型是蛋白酶進行水解作用的關鍵，根據文獻指出SRIF-28中Pro6與Pro10有助於增加
並列摘要
The octacosapeptide somatostatin-28 (SRIF-28), a NH2-terminally extended somatostatin, containing 28 residues, was first isolated from ovine hypothalamic extracts. The primary structure of SRIF-28 is :H-Ser1-Ala2-Asn3- Ser4-Asn5-Pro6-Ala7-Met8-Ala9-Pro10-Arg11-Glu12-Arg13-Lys14-Ala15-Gly16-c[Cys17-Lys18-Asn19-Phe20-Phe21-Trp22-Lys23-Thr24-Phe25-Thr26-Ser27-Cys28]-OH. A single arginine residue forms the proteolytic cleavage site for the processing of SRIF-28. A
參考文獻
1. Jean E. R., Dean A. K., Judit E., Beatrice W., Ve´ronique E., Renzo C., and Jean C. R., “Somatostatin Receptor 1 Selective Analogues: 3. Dicyclic Peptides.” J. med. Chem., Vol. 48, pp.515-522(2005)
2. Brazeau, P., Vale, W., Burgus, R., Ling, N., Butcher, M., Rivier, J., ―Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone .” Science, Vol.179, 77–79(1973).
3. Pradayrol, L., Jornvall, H., Mutt, V., Ribet, A., “N-terminally extended somatostatin:the primary structure of somatostatin-28.” FEBS Lett, Vol. 1019, pp. 55-58(1980).
參考文獻
4. Pradayrol, L., Jornvall, H., Mutt, V., Ribet, A., “Prosomatostatin processing in Neuro2 A cells Role of
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