並列摘要
Asthma and obesity in adults and children are increasing worldwide public health problems, especially in developed countries. Obese and overweight children have increased rates of both atopic and non-atopic wheezing due to a variety of known and proposed mechanisms. These include reduced lung volume and airway caliber due to increased chest wall mass and possible airway inflammation from systemic inflammation as a result of increased adiposity that includes macrophage accumulation and the effects of the proinflammatory energy-regulating hormone, leptin. Comorbidities that aggravate wheezing include gastro-esophageal reflux disease, type 2 diabetes, metabolic syndrome, and, possibly, dyslipidemia. Children with asthma and obesity appear to be more resistant to both outpatient and inpatient medical treatment and weight loss is the definitive therapy.
被引用紀錄
延伸閱讀
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