Effects of Sensitization to ＂Dermatophagoides Pteronyssinus＂ and ＂Dermatophagoides Farinae＂ on Pulmonary Function and Bronchodilator Response in Asthmatic Children

Yu-Tsun Su ； Chien-Yi Wu ； Chia-Chang Tsai ； Ying-Chun Li ； Yung-Cheng Lin ； Yu-Cheng Tsai ； Chen-Kuang Niu

《中華民國兒童胸腔醫學會雜誌》 9卷4期 (2013/12) Pp. 74-80

https://doi.org/10.6322/JPRD.201312_9(4).0001

並列摘要

Background: Both sensitization to aeroallergens and pulmonary function test are important to the diagnosis and treatment of asthma; however, the relationship between these two factors remains unclear. Objectives: To explore the relationship between sensitization to Dermatophagoides pteronyssinus (Der p) or Dermatophagoides farinae (Der f) and pulmonary function (FEV_1/FVC, FEV_1, FEF_(25-75), and bronchodilator response (BDR)). Methods: A hospital based, retrospective study of asthmatic children receiving specific allergen tests (MAST-CLA sem) and pulmonary function test results between 2004 and 2006. Participants were categorized into four groups according to positive or negative sensitization to Der p or Der f by MAST report. We compared FEV_1/FVC, mean FEV_1, mean FEF_(25-75), prevalence rates of FEV_1 ＜ 80%, FEF_(25-75) ＜ 65%, and BDR (change of FEV_1 after bronchodilator) ≥ 12%. Results: Sixty-three asthmatic children (10.2 ± 2.1 y/o) were enrolled. Fifty-four percent were found to be sensitive to Der p, and 59% to Der f. No significant differences were found in the mean FEV_1, mean FEF_(25-75), the prevalence rate of FEV_1 ＜ 80% in either those sensitive to Der p or Der f group, compared to the non-sensitization groups. However, a significantly greater number children with sensitization to Der f had FEF25-75 below 65% than those not sensitization to Der f (p ＜ 0.05). This was not found in the Der p groups. Each sensitization group had a significantly higher prevalence rate of BDR ≥ 12% than its respective non-sensitization group (both p ＜ 0.05). Conclusions: Sensitization to Der f plays a more important role in reduced FEF_(25-75) ＜ 65% than Der p. There is a significant relationship between BDR ≥ 12% and sensitization to Der p and Der f in asthmatic children, which suggest that pre-bronchodilator and post-bronchodilator spirometry are needed to evaluate airway reversibility in asthmatic children, especially in atopic asthma.

並列關鍵字

asthmatic children ； mite sensitive ； pulmonary function ； bronchodilator response