Effect of Local Massage on Vaccination: DTP and DTPa

局部按摩對疫苗接種效果影響之研究－以百日咳疫苗爲模式

黃富源(Fu-Yuan Huang) ； 黃立民(Li-Min Huang)

《Acta Paediatrica Sinica》 40卷3期 (1999/06) Pp. 166-170

https://doi.org/10.7097/APS.199906.0166

摘要

我們以前研究發現局部按摩一分鍾可以加強白喉、百日咳、破傷風混合疫苗(CTPw)的免疫效果，本研究進一步探討更強烈的局部處置(按摩併敷)對傳統白喉、百日咳、破傷風混合疫苗及白喉、非細胞性百日咳、破傷風混合疫苗(DTPa)的影響。我們一共收集808名兩個月大兒童，分成四組。一組接種DTPw但無局部處置、一組接種DTPw並給予局部處置、一組接種DTPa但無局部處理、一組接種DTPa並給予局部處理。結果顯示不管有無局部處置對於副作用的發生頻率大致上並無統計上差異。唯一統計上有差異者在於前兩劑注射後若有局部處置則局部腫痛都有增加。而各種抗體的産生在局部處置組與無處置組之間並並無統計上差異。因此局部處置的強度對疫苗的副作用及抗體的産生有影響，局部處置太強烈反而得不到好處，只是增加了局部副作用。局部按摩兩分鍾對注射DTPa並無好處。

關鍵字

白喉 ； 百日咳 ； 破傷風混合疫苗 ； 局部按摩 ； 副作用 ； 抗體

並列摘要

We previously demonstrated that local massage for one minute can enhance immunogenicity of diphtheria, tetanus, and whole-cell pertussis (DTPw) vaccination. This study further analyzes the effects of more intense local manipulation on infants after DTPw and DTPa (diphtheria, tetanus, and acellular pertussis) vaccination. A total of 808 infants aged two months were recruited to be vaccinated with either DTPw or DTPa. Vaccinees in both groups were further divided into two groups; those receiving local manipulation (massage and hot packing after vaccinations) and those receiving only vaccinations. Results showed that safety profiles were largely similar between those who had local manipulation following vaccination and those without. The only significant difference was more frequent local reactions including pain and swelling following the first two doses in both the DTPa and DTPw groups receiving manipulation compared with the groups not receiving manipulation. Serologic tests revealed that local manipulation had no significant effect on antibody response to pertussis toxin and filamentous hemagglutinin, and diphtheria and tetanus toxins. The effect of local massage on DTPw was related to the intensity of local massage. Too vigorous a local manipulation caused adverse local reactions and no beneficial effect on antibody response. As for the infants receiving DTPa and local massages for two minutes with hot packing, no significant effect on either the reactogenicity or immunogenicily was found.

並列關鍵字

DTP ； DTPa ； local massage ； adverse reactions ； immunogenicity