透過您的圖書館登入
IP:3.145.151.141
  • 期刊

Activation of IGF-I Survival Signaling and Its Compensative Inhibition of the Cardiac Apoptosis on Carotid Arteries Balloon-Injured Rat Hearts

本篇文章尚未正式出版,請點選「加入追蹤」跟進後續出版資訊!

摘要


In this study, a rat carotid balloon injury-animal model was used to elucidate the temporal relation of hypertrophy in the progression of cardiac damage and the role of insulin-like growth factor (IGF)-I survival pathway on course of the cardiac damage. Rats were subjected to carotid balloon-injury and examined at different time points. We further studied the heart-weight/body-weight-ratio, histology and protein expression to understand the pathological events associated with percutaneous transluminal coronary angioplasty (PTCA) induced damages. Protein expression analysis showed increased levels of IGF-I signaling pathway and mitogen-activated protein kinase (MAPK) signaling pathway after 2 h and after 2 d of carotid balloon injury. On the other hand, apoptosis signaling pathways were enhanced after 14 d of carotid balloon injury. According to the results, rat carotid balloon injury significantly induced IGF-I survival signaling and compensated hypertrophy pathway during the initial period of injury however after 14 d the proteins involved in apoptotic cell death were elevated and the proteins of the survival pathway and compensatory hypertrophy were significantly reduced.

參考文獻


Ju, D.T.,Liao, H.E.,Shibu, M.A.,Ho, T.J.,Viswanadha, V.P.,Tsai, F.J.,Chung, L.C.,Day, C.H.,Lin, C.C.,Huang, C.Y.(2015).Nerve regeneration potential of protocatechuic acid in RSC96 Schwann cells by induction of cellular proliferation and migration through IGF-IR-PI3K-Akt signaling.Chinese J. Physiol..58,412-419.
Chen, W.K.,Yeh, Y.L.,Lin, Y.M.,Lin, J.Y.,Tzang, B.S.,Lin, J.A.,Yang, A.L.,Wu, F.L.,Tsai, F.J.,Cheng, S.M.,Huang, C.Y.,Lee, S.D.(2014).Cardiac hypertrophy-related pathways in obesity.Chinese J. Physiol..57,111-120.
Ju, D.T.,Liao, H.E.,Shibu, M.A.,Ho, T.J.,Viswanadha, V.P.,Tsai, F.J.,Chung, L.C.,Day, C.H.,Lin, C.C.,Huang, C.Y.(2015).Nerve regeneration potential of protocatechuic acid in RSC96 Schwann cells by induction of cellular proliferation and migration through IGF-IR-PI3K-Akt signaling.Chinese J. Physiol..58,412-419.
Chen, H.I.(2012).Hemodynamic mechanism of ventricular hypertrophy in hypertension.Chinese J. Physiol..55,369-379.
Alexopoulos, D.,Xanthopoulou, I.,Davlouros, P.,Damelou, A.,Mazarakis, A.,Chiladakis, J.,Hahalis, G.(2010).Mechanisms of nonfatal acute myocardial infarction late after stent implantation: the relative impact of disease progression, stent restenosis, and stent thrombosis.Am. Heart J..159,439-445.

延伸閱讀