Effects of B Vitamins Overload on Plasma Insulin Level and Hydrogen Peroxide Generation in Rats

Wuping Sun ； Mingzhu Zhai ； Qian Zhou ； Chengrui Qian ； Changyu Jiang

《The Chinese Journal of Physiology》 60卷4期 (2017/08) Pp. 207-214

https://doi.org/10.4077/CJP.2017.BAF469

摘要

It has been reported that nicotinamide-overload induces oxidative stress associated with insulin resistance, the key feature of type 2 diabetes mellitus (T2DM). This study aimed to investigate the effects of B vitamins in T2DM. Glucose tolerance tests (GTT) were carried out in adult Sprague-Dawley rats treated with or without cumulative doses of B vitamins. More specifically, insulin tolerance tests (ITT) were also carried out in adult Sprague-Dawley rats treated with or without cumulative doses of Vitamin B3. We found that cumulative Vitamin B1 and Vitamin B3 administration significantly increased the plasma H_2O_2 levels associated with high insulin levels. Only Vitamin B3 reduced muscular and hepatic glycogen contents. Cumulative administration of nicotinic acid, another form of Vitamin B3, also significantly increased plasma insulin level and H_2O_2 generation. Moreover, cumulative administration of nicotinic acid or nicotinamide impaired glucose metabolism. This study suggested that excess Vitamin B1 and Vitamin B3 caused oxidative stress and insulin resistance.

關鍵字

B vitamins ； insulin resistance ； nicotinamide ； nicotinic acid ； oxidative stress

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