摘要
Stroke is the second leading cause of death and the leading cause of adult disability worldwide. Despite an impressive amount of neuroprotective agents that has been identified in experimental stroke, none of them proved efficient in clinical trials. There is a general consensus that an effective treatment requires the ability to interact with not one, but multiple pathophysiological cascades at different levels that induced by the insult - cocktail therapy. Luckily, recent progress in the field of epigenetics revealed that epigenetic modifications had influence on many known pathways involved in the complex course of ischemic disease development. The fact that epigenetic molecules, by altering transcriptional regulation, may simultaneously act on different levels of ischemic brain injury makes them promising candidates for clinical use. These modifications arise typically owing to deoxyribonucleic acid methylation and histone acetylation. The aim of this review is to give a comprehensive overview of current advances in stroke epigenetics, in particular, the physiological and pathological functions of the 11 classical histone deacetylases.
參考文獻
延伸閱讀
- 王惟德、董育瑞、張子瑩、江裕陽（2010）。Case Report of Stroke Sequelae Patient。北市中醫會刊，16(2)，29-36。https://doi.org/10.6718/TJCMb.201006_16(2).0002
- Wagner, A. P., Filfan, M., Uzoni, A., Pourgolafshan, P., & Buga, A. M. (2015). Poststroke Cell Therapy of the Aged Brain. Neural Plasticity, 2015(), 391-397-132. https://doi.org/10.1155/2015/839638
- 馮啟揚、張權維、連倚南（1989）。Study of Onset Time in Infarction Stroke。中華民國復健醫學會雜誌，(17)，21-24。https://www.airitilibrary.com/Article/Detail?DocID=10253009-198912-x-17-21-24-a
- Licciardi, P. V., Ververis, K., & Karagiannis, T. C. (2011). Histone Deacetylase Inhibition and Dietary Short-Chain Fatty Acids. ISRN Allergy, (), 14-21. https://www.airitilibrary.com/Article/Detail?DocID=20905521-201112-201202230023-201202230023-17-24
- 吳鑫漢、蘇瑞芬、連倚南（1977）。ADL Follow-up of Post-Stroke Patients。中華民國復健醫學會雜誌，(5)，29-29。https://www.airitilibrary.com/Article/Detail?DocID=10253009-197712-x-5-29-29-o