- 期刊
Associations of postprandial lipemia with trunk/leg fat ratio in young normal weight women independently of fat mass and insulin resistance
摘要
Background and Objectives: To determine whether postprandial lipemia is associated with fat distribution even in young, normal weight women independently of fat mass, adipokines, insulin resistance and systemic inflammation. Methods and Study Design: Female college students (ages 21-24, n=35) underwent dual-energy X-ray absorptiometry and a standardized breakfast providing 17 g triglycerides (TG). Serum lipids, lipoproteins, apolipoproteins, adipokines and markers of insulin resistance and inflammation were measured in fasting blood samples. Results: In crude analyses, postprandial lipemia, as assessed by 0-2 h area under the curve of serum TG (TG-AUC), was positively associated with fasting TG, trunk/leg fat ratio, apolipoprotein B, leptin/adiponectin ratio and log high-sensitivity CRP. Multiple linear regression analysis with these 5 variables as independent variables revealed that fasting TG (p＜0.001) and trunk/ leg fat ratio (p=0.001), were independent positive predictors of TG-AUC (R^2=0.923). Women with high compared to low TG-AUC were characterized by higher trunk/leg fat ratio, elevated apolipoprotein B and leptin/adiponectin ratio. Conclusion: Trunk/leg fat ratio, a marker of central adiposity, is a significant predictor of postprandial lipemia even in young women who are normal weight and insulin- sensitive, suggesting a modifiable pathway to postprandial hypertriglyceridemia, a cardiometabolic risk factor. These findings should be confirmed in studies employing more participants.
延伸閱讀
- Hageman, P. A., Pullen, C. H., Hertzog, M., Boeckner, L. S., & Walker, S. N. (2012). Associations of Cardiorespiratory Fitness and Fatness with Metabolic Syndrome in Rural Women with Prehypertension. Journal of Obesity, 2012(), 710-718. https://doi.org/10.1155/2012/618728
- Qu, H., Deng, H., & Hu, Z. (2013). Plasma Progranulin Concentrations Are Increased in Patients with Type 2 Diabetes and Obesity and Correlated with Insulin Resistance. Mediators of Inflammation, 2013(), 54-59-105. https://doi.org/10.1155/2013/360190
- 何忠鋒、胡雲雯、周資眾（2005）。Effects of a Twelve-Week Weight Loss Program on Blood Lipids and Health-Related Physical Fitness in Obese Postmenopausal Women。大專體育學術專刊，()，591-599。https://doi.org/10.6695/AUES.200505_94.0059
- Rocha, P. M., Barata, J. T., Minderico, C. S., Silva, A. M., Teixeira, P. J., & Sardinha, L. B. (2011). Visceral Abdominal and Subfascial Femoral Adipose Tissue Have Opposite Associations with Liver Fat in Overweight and Obese Premenopausal Caucasian Women. Journal of Lipids, 2011(), 23-33. https://doi.org/10.1155/2011/154672
- Yang, H. R., & Chang, E. J. (2016). Insulin resistance, body composition, and fat distribution in obese children with nonalcoholic fatty liver disease. Asia Pacific Journal of Clinical Nutrition, 25(1), 126-133. https://doi.org/10.6133/apjcn.2016.25.1.15