台灣南部地區某山地鄕C型肝炎病毒血清流行病學研究

Seroepidemiology of Hepatitis C Virus among Residents of an Aboriginal Township in Southern Taiwan

黃凱琳(Kai-Lin Hwang) ； 游山林(San-Lin You) ； 王秋華(Chiu-Hwa Wang) ； 朱健次(Chien-Ts Chu) ； 楊照雄(Czau-Siung Yang) ； 陳建仁(Chien-Len Chen)

《中華民國公共衛生學會雜誌》 11卷2期 (1992/06) Pp. 124-130

https://doi.org/10.6288/JNPHARC1992-11-02-05

摘要

台灣地區一般人口的C型肝炎病毒(HCV)抗體陽性率約在1%左右。由於第一型人類T細胞白血病病毒(HTLV-Ⅰ)和HCV同屬體液傳染病毒，本研究乃以HTLV-Ⅰ感染率偏高的高雄縣桃源鄉為研究地區，調查當地居氏的HCV抗體陽性率，並辨明是否有家族聚集的現象。總共以隨機抽樣選取119家戶之398名成員為研究對象，利用放射免疫分析法測定血清中之B型肝炎表面抗原(HBsAg)，而以酵素免疫分析法儉驗HCV抗體陽性狀態，並且根據結構式問卷調查人口學特徵，以及輸血、刺青既往史。研究結果發現，當地居民之HCV抗體陽性率高達5.8%(23/398)，而且隨年齡增加而顯著上升，於30-39歲達最高峰(17.0%)，而彼下降。HCV抗體之年齡標準化陽性率，男性(6.5%)略高於女性(4.7%)，已婚者(4.7%)高於未婚者(1.3%)，有輸血既往史者(5.3%)略低於無既往史者(5.5%)，閩南籍(5.5%)與山地籍(6.0%)相近，各變項均與HCV抗體陽性率無顯著相關。HBsAg帶原者的HCV抗體年齡標準化陽性率(7.6%)亦僅略高於非帶原者(5.0%)。雖然有兩戶家庭各有兩名陽性個案，其家屬關係分別為夫妻和公媳，但統計分析顯示無明顯家族聚集現象存在。當地居民HCV抗體陽性率偏高之原因，有待進一步探討。

並列摘要

The positivity rate of antibody to hepatitis C virus (anti-HCV) was reported as 1% for the general population of Taiwan. Both human leukemia/lymphoma virus type-I (HTLV-I) and HCV are body fluid-transmitted viruses, residents of an aboriginal township with a high prevalence of HTLV-I was studied to examine the positive rate and familial aggregation of anti HCV. A total of 398 subjects in 119 randomly selected housholds were recruited. The hepatitis B surface antigen (HBsAg) carrier status and anti-HCV positivity were examined by radioimmunoassay and enzyme immunoassay, respectively using commercial kits. Sociodemographic characteristics and history of blood transfusion and tattooing were obtained through standardized interviews based on structured guestionnaires. The anti-HCV positive rate of study subjects was as high as 5.8% (23/398). It increased with age and peaked at ages of 3039 years. The age-adjusted anti-HCV positive rate was 6.5% and 4.7%, respectively, among males and females. There was no significant association of age-adjusted anti-HCV positive rate with marital status, history of blood transfusion, and paternal and maternal ancestry. HBsAg carriers had slightly higher age-adjusted anti-HCV positive rate (7.6%) than non-carriers. Although there were two families with two family members infected by HCV, no statistically significant familial aggregation was observed. The reasons for the extraordinarily high anti-HCV positive rate among residents in the township remain to be elucidated.

並列關鍵字

HCV ； HTLV-I ； Epidemiology ； Aborigional township