- 期刊
- OpenAccess
Effect of Prior Antiplatelet Therapy on Major Adverse Cardiac Events in Patients Diagnosed with Infective Endocarditis: Population‑Based Retrospective Cohort Study
摘要
Background: Infective endocarditis (IE) occurs with an incidence of about 3-10 per 100,000 person-years globally. Those with infective endocarditis complicated embolic events have worse outcomes. However, whether antiplatelet therapy could prevent the development of ischemic stroke and myocardial infarction remained unknown. Materials and Methods: We conducted a retrospective cohort study using Taiwan National Health Insurance Research Database to access the effect of prior antiplatelet therapy on major adverse cardiac events in patients diagnosed with infective endocarditis. Results: The clinical characteristics and the risk of subsequent major adverse cardiac events in 901 patients with infective endocarditis with prior antiplatelet therapy and a matched cohort without antiplatelet therapy were retrospectively analyzed. The majority (63%) of the patients with prior antiplatelet therapy were male and 568 (57.7%) had a high (≥3) Charlson Cormorbidity Index score. There was no significant difference in the risk of myocardial infarction, ischemic stroke, and major bleeding between the two groups. The tests of interaction showed the risk of myocardial infarction was contingent on heart failure. Conclusions: Prior antiplatelet therapy did not prevent the cerebral and myocardial infarction in those with infective endocarditis. Neither did them increase the risk of major bleeding in patients with infective endocarditis.
延伸閱讀
- Raza, F., Alkhouli, M., Sandhu, P., Bhatt, R., & Bove, A. A. (2014). Elevated Cardiac Troponin in Acute Stroke without Acute Coronary Syndrome Predicts Long-Term Adverse Cardiovascular Outcomes. Stroke Research and Treatment, (2014), 170-175. https://doi.org/10.1155/2014/621650
- Hayashi, H., Fukuda, H., Hasegawa, T., Takahama, H., Amaki, M., Kanzaki, H., Sakamoto, M., Maeda, M., Sata, M., Ito, S., Izumiya, Y., Yoshiyama, M., & Kitakaze, M. (2020). Impact of Comorbidity of Chronic Obstructive Pulmonary Disease on Cardiovascular Events and Prognosis in Patients with Chronic Heart Failure: A Single-Center Retrospective Observational Study. International Journal of Gerontology, 14(4), 298-303. https://doi.org/10.6890/IJGE.202011_14(4).0009
- Yang, S. C., Wang, Y. C., Hwang, J. J., Hsu, K. L., Chiang, F. T., & Tseng, C. D. (2010). Predictors of In-Hospital Mortality in Patients with Successful Primary Coronary Intervention for Acute ST-Elevation Myocardial Infarction Presenting as Cardiogenic Shock. Acta Cardiologica Sinica, 26(2), 81-88. https://www.airitilibrary.com/Article/Detail?DocID=10116842-201006-201007050079-201007050079-81-88
- 陳世芹（2011）。Duration of Dual Antiplatelet Therapy and Recurrent Cardiovascular Events for Patients with Acute Coronary Syndrome〔碩士論文，國立臺灣大學〕。華藝線上圖書館。https://doi.org/10.6342/NTU.2011.10452
- Lee, C. W., Tsai, F. F., Su, M. I., Yeh, H. I., Chiang, Y. T., Hsieh, C. F., & Chen, C. Y. (2019). Effects of Clopidogrel and Proton Pump Inhibitors on Cardiovascular Events in Patients with Type 2 Diabetes Mellitus after Bare Metal Stent Implantation: A Nationwide Cohort Study. Acta Cardiologica Sinica, 35(4), 402-411. https://doi.org/10.6515/ACS.201907_35(4).20190108B