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Relationship between Helicobacter Pylori Infection and Gastric Dysplasia: Results from Histology of Gastric Samples in the South of Iran
摘要
Background and Study Aims: Gastric dysplasia (GD) is a histologic premalignant lesion. Its significant lies in its strong association with the increased risk of developing gastric cancer. As there is no data about the frequency of Helicobacter pylori infection in histologic GD in the south of Iran, we designed the current study. Patients and Methods: In this cross‑sectional study, we studied the frequency of H. pylori infection in consecutive cases with histologic diagnosis of GD; then, they were compared with a randomly selected group of age‑matched participants whose histological diagnosis was normal or mild inflammation. The current study was conducted from November 2010 to January 2017 in Iran. Results: Of a total of 3521 patients, 126 cases with GD and 252 participants as the controls were enrolled. The mean age ± standard deviation of GD patients and controls was 50.25 ± 17.708 and 50.16 ± 17.388 years, respectively. Histologically, H. pylori infection was detected in 84.9% and 73.4% of the GD patients and controls, respectively. The frequency of H. pylori in the GD group was significantly higher than the comparison group (P = 0.012). On gastric endoscopic examination of patients with GD, 31 (24.6%) patients had normal endoscopy and others had abnormal endoscopic findings. Conclusions: In our study, the frequency of H. pylori in patients with GD was significantly higher than that of the comparison group. We recommend that further studies can be conducted to clarify the causal relationship of H. pylori infection and GD and also the impact of H. pylori eradication on the natural course of GD. We also recommend that further studies can be performed to determine the real association between endoscopic findings and GD.
延伸閱讀
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