Background and Aims of the Study: Given the effectiveness of handwashing in preventing nosocomial infections and key role of nurses as a care provider in ensuring the well-being of individuals and society, this study aimed to determine the predictive power of BASNEF model constructs on this behavior. Materials and Methods: This descriptive analytical study was conducted on a total of 498 nurses working at hospitals based in Ardabil and Khalkhal during 2018. The participants were selected through a multistage sampling method. The data were collected by a valid and reliable questionnaire based on the BASNEF model constructs and analyzed through the SPSS 18, using statistical tests including t-test, ANOVA, Pearson's correlation, and multiple linear regressions, considering the significant level lower than 5%. Results: There was a significantly negative correlation between age/work experiences with hand hygiene (HH) behavior. Moreover, the attitude toward behavior showed a significantly positive correlation with the enabling factors and a significantly negative correlation with the subjective norms. The results of multiple linear regression indicated that the BASNEF model components had a predictive power of 3%, which was raised to 21.8% as age and work experience were added to the regression model. Hence, age and work experience were two important factors in predicting the hygiene behavior. Conclusions: The BASNEF model components cannot predict HH behavior among nurses, but age and work experience were two important factors in predicting the hygiene behavior.
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