Correlation between Gout and Coronary Heart Disease in Taiwan: A Nationwide Population-Based Cohort Study

Kuang-Hua Huang ； Chih-Jaan Tai ； Ya-Fang Tsai ； Yu-Hsiang Kuan ； Chien-Ying Lee

《Acta Cardiologica Sinica》 35卷6期 (2019/11) Pp. 634-640

https://doi.org/10.6515/ACS.201911_35(6).20190403B

摘要

Background: Gout is the most common inflammatory arthritis in adult males. Patients with gout are at a higher risk of coronary heart disease (CHD). This study aimed to investigate the correlation between gout and CHD. Methods: This was a retrospective cohort study that used data from the Longitudinal Health Insurance Database of Taiwan. The study subjects were 46,140 patients with new-onset gout during 2003-2010. To avoid selection bias, we used propensity score matching. A Cox proportional hazard model was used to analyze differences in the risk of CHD between patients with and without gout after controlling for related variables. Results: The patients with gout had a higher risk of CHD than the patients without gout [adjusted hazards ratio (HR) = 1.34, 95% confidence interval (CI): 1.23-1.45]. The risk of CHD increased with older age. Other related factors for CHD included gender (female vs. male, adjusted HR = 0.86, 95% CI: 0.79-0.93), hypertension (adjusted HR = 1.53, 95% CI: 1.42-1.65), hyperlipidemia (adjusted HR = 1.18, 95% CI: 1.07-1.29), and diabetes mellitus (adjusted HR = 1.24, 95% CI: 1.13-1.36). Conclusions: We found correlations between gout and CHD and other influencing factors including hypertension, hyperlipidemia, and diabetes mellitus. We also found that gender and age were associated with CHD.

關鍵字

Coronary heart disease ； Gout ； Hyperuricemia ； Risk factor