台北地區醫院產檢孕婦的葉酸營養狀況

The Folate Status of Pre-natal Follow up Pregnant Women at Hospital in Taipei

陳冠如(Kuan-Ju Chen) ； 蕭寧馨(Ning-Sing Shaw) ； 林璧鳳(Bi-Fong Lin)

《中華民國營養學會雜誌》 31卷1期 (2006/03) Pp. 8-16

https://doi.org/10.6691/JCNS.200603_31(1).0002

摘要

The purpose of this study was to investigate the folate status of pregnant women in Taipei. Eighty-one pregnant women who received prenatal follow-up at Geng-Xin or Ya-Dong Hospital, aged 20 to 35 years and who did not have anemia (hemoglobin＞11g/dL) were recruited as study subjects. Fasting blood samples were collected from subjects during the early stage (＜18 weeks), late stage (19~36 weeks), at delivery, and the postpartum stage (6 weeks after delivery) to measure folate. The results showed that the average plasma folate level dropped to the lowest point during late pregnancy (11.6±8.2ng/mL) and at delivery (11.8±7.2ng/mL), and was significantly higher at 6 weeks postpartum (14.8±7.5ng/mL). The average red bleed cell folate was the lowest during early pregnancy (478±255ng/mL), slightly increased during late pregnancy (558+311ng/mL) and at delivery (677±358ng/mL), and were significantly higher during the postpartum period (805±267ng/mL). There were 13.6% pregnant women in the early stage with marginal folate deficiency (plasma folate of 3~6ng/mL), and 10% with folate deficiency (plasma folate＜3ng/mL) and 21% with marginal folate deficiency during late pregnancy. When evaluated by RBC folate, there were 12.1% of women with folate insufficiency during early pregnancy, including 3.7% with folate deficiency (RBC folate of＜160ng/mL) and 7.4% with marginal folate deficiency (RBC folate of 160~200ng/mL). Although most pregnant women with a poor RBC folate status had recovered by 6 weeks after delivery, 11% of the postpartum women still had a poor plasma folate status at that time. Our study indicates that one-tenth of pregnant women had a poor folate status during early pregnancy, and up to one-third during late pregnancy. Therefore, folate nutrition still needs be emphasized during pregnancy to avoid any possible fetal and maternal health problems.

關鍵字

葉酸 ； 孕婦葉酸營養狀況 ； 血漿葉酸 ； 紅血球葉酸

並列摘要

The purpose of this study was to investigate the folate status of pregnant women in Taipei. Eighty-one pregnant women who received prenatal follow-up at Geng-Xin or Ya-Dong Hospital, aged 20 to 35 years and who did not have anemia (hemoglobin＞11g/dL) were recruited as study subjects. Fasting blood samples were collected from subjects during the early stage (＜18 weeks), late stage (19~36 weeks), at delivery, and the postpartum stage (6 weeks after delivery) to measure folate. The results showed that the average plasma folate level dropped to the lowest point during late pregnancy (11.6±8.2ng/mL) and at delivery (11.8±7.2ng/mL), and was significantly higher at 6 weeks postpartum (14.8±7.5ng/mL). The average red bleed cell folate was the lowest during early pregnancy (478±255ng/mL), slightly increased during late pregnancy (558+311ng/mL) and at delivery (677±358ng/mL), and were significantly higher during the postpartum period (805±267ng/mL). There were 13.6% pregnant women in the early stage with marginal folate deficiency (plasma folate of 3~6ng/mL), and 10% with folate deficiency (plasma folate＜3ng/mL) and 21% with marginal folate deficiency during late pregnancy. When evaluated by RBC folate, there were 12.1% of women with folate insufficiency during early pregnancy, including 3.7% with folate deficiency (RBC folate of＜160ng/mL) and 7.4% with marginal folate deficiency (RBC folate of 160~200ng/mL). Although most pregnant women with a poor RBC folate status had recovered by 6 weeks after delivery, 11% of the postpartum women still had a poor plasma folate status at that time. Our study indicates that one-tenth of pregnant women had a poor folate status during early pregnancy, and up to one-third during late pregnancy. Therefore, folate nutrition still needs be emphasized during pregnancy to avoid any possible fetal and maternal health problems.

並列關鍵字

folate ； folate status of pregnancy ； plasma folate ； RBC folate