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Calcium Polystyrene Sulfonate (Kalimate)-Related Colonic Necrosis in a Uremic Patient
摘要
Currently, Kalimate (calcium polystyrene sulfonate) is widely used to treat hyperkalemia. In the past, sodium polystyrene sulfonate (Kayexalate) mixed with sorbital has caused gastrointestinal tract lesions, such as loose stool and hematochezia. Although rare, colonic necrosis and perforation are very severe complications associated with the medication. In this case report, we present an 85-year-old man with a history of uremia who has been undergoing hemodialysis for 2 years and was admitted due to pneumonia with severe sepsis and acute respiratory failure. We used Kalimate (calcium polystyrene sulfonate) which was administered orally and suspended in distilled water rather than in sorbital for treatment of refractory hyperkalemia. After the third day of administering this medication however, profuse hematochezia developed and it presented the same clinical manifestation and histologic lesions as Kayexalate-related colonic necrosis. Kalimate-related colonic necrosis is a rare, but is considered a life-threatening complication. We expect to remind clinicians of the possible and severe adverse effects of this commonly administered medication.
延伸閱讀
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