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Stromal Cell-Derived Factor 1 is Associated with Inflammatory and Nutritional Markers in Hemodialysis Patients
摘要
BACKGROUND: Stromal cell-derived factor 1 (SDF-1) functions to maintain homeostatic tissue renewal and regeneration upon renal injury but its effects were not clear on hemodialysis (HD) patients. METHODS: In December 2007, 152 HD patients were enrolled and received follow up until December 2012. Matrix metalloproteinase-2/-9 (MMP-2/-9), myeloperoxidase (MPO), osteopontin and SDF-1 were measured by enzyme linked immunosorbent assay. The Geriatric Nutritional Risk Index (GNRI) score was calculated by modifying the Nutritional Risk Index (NRI) for elderly patients based on the following formula: GNRI = [14.89 x albumin (g/dL)] + [41.7 x (body weight [BW]/ideal BW)]. Fifty persons with normal renal function were enrolled as a control group. RESULTS: The average age of subjects in the control group was 40.06 ± 16.54 years old and the average serum creatinine was 0.76 ± 0.17 mg/dL. The average age of HD patients was 58.7 ± 14.07 years old. As compared with control group, the HD group had higher SDF-1 (2,946.62 ± 1,314.2 pg/mL vs. 2,242.99 ± 607.84 pg/mL, P ＜ 0.001) and MPO (64.9 ± 24.15 ng/mL vs. 55.39 ± 15.01 pg/mL, P = 0.012), but lower osteopontin (21.35 ± 41.02 ng/mL vs. 90.46 ± 130.87 ng/mL, P = 0.017), MMP-2 (455.89 ± 175.15 ng/mL vs. 517.8 ± 220.86 ng/mL, P = 0.077) and MMP-9 (334.24 ± 179.18 ng/mL vs. 1,165.05 ± 545.07 ng/mL, P ＜ 0.001). SDF-1 level indicated positive correlations with MMP-2 (r = 0.31, P ＜ 0.001), MMP-9 (r = 0.19, P = 0.021), MPO (r = 0.532, P ＜ 0.001) and oeteopontin (r = 0.31, P ＜ 0.001), and negative correlations with albumin (r = -0.192, P = 0.018), GNRI score (r = -0.227, P = 0.007), and normalized protein catabolic ratio (r = -0.21, P = 0.012). CONCLUSION: SDF-1 may have a role in influencing the inflammation and nutrition status of HD patients but further studies are necessary to investigate this possibility.
延伸閱讀
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