CKD Patients with Higher BMI but without Metabolic Syndrome Have Better Outcome and Survival

Keng-Chu Ko ； Chun-Chieh Tsai ； Chia-Lin Wu ； Chew-Teng Kor ； Chia-Chu Chang ； Ping-Fang Chiu

《Acta Nephrologica》 31卷2期 (2017/06) Pp. 76-83

https://doi.org/10.6221/AN.2017005

摘要

BACKGROUND: Both obesity and metabolic syndrome are major risk factors of chronic kidney disease (CKD). However, the relations between CKD and these two conditions are not constant in previous studies. We aimed at discovering correlations between body mass index (BMI), metabolic syndrome and CKD disease progression. METHODS: A total of 1,502 patients with late CKD or proteinuria in 2001 ~ 2015 were included for analysis. The endpoints were set to disease progression to end-stage renal disease (ESRD) or death. Patients were divided into different groups according to their BMI and metabolic syndrome status. (BMI ≥ 27 defined as obesity; with or without metabolic syndrome) We analyzed the effect of BMI and metabolic syndrome on CKD progression and mortality. RESULTS: The main result was that patients with BMI ≥ 27 had a lower risk of ESRD and death during the study period. The difference was more significant in patients who was obese but did not have metabolic syndrome. The impact of metabolic syndrome to ESRD and death was hazardous but not statistically significant. CONCLUSION: CKD patients with higher BMI have a better outcome of CKD progression and death, especially in those without metabolic syndrome.

關鍵字

CKD ； ESRD ； metabolic syndrome ； obesity