- 期刊
- OpenAccess
Association of Osteoprotegerin and Aortic Artery Stiffness in Adult Peritoneal Dialysis Patients
摘要
BACKGROUND: Cardiovascular disease is still a major cause of mortality in patients undergoing peritoneal dialysis (PD), and osteoprotegerin (OPG) is associated with aortic artery stiffness. In this study, we evaluated the relationship between aortic artery stiffness measured by carotid-femoral pulse wave velocity (cfPWV) and serum OPG levels in patients undergoing PD. METHODS: Fasting blood samples were obtained from 68 patients with PD, and cfPWV was measured using a validated tonometry system. Serum OPG levels were measured using a commercial enzyme-linked immunosorbent assay kit. RESULTS: Among 68 patients with PD, 20 patients (29.4%) were included in the aortic artery stiffness group. The aortic artery stiffness group had older age (P = 0.003), longer PD vintage (P = 0.007), and higher serum OPG level (P ＜ 0.001) than the control group. Multivariate logistic regression analysis of the factors significantly associated with aortic artery stiffness revealed that OPG (odds ratio [OR] = 1.027, 95% confidence interval [CI] = 1.011-1.044, P = 0.001), age (OR = 1.132, 95% CI = 1.020-1.256, P = 0.019), and PD vintage (OR = 1.034, 95% CI = 1.011-1.057, P = 0.004) were independent predictors of aortic artery stiffness in patients undergoing PD. Multivariate forward stepwise linear regression analysis showed that serum OPG level (β = 0.363, adjusted R^2 change = 0.139, P = 0.002) was positively associated with cfPWV values in these patients. CONCLUSION: Serum OPG level is positively correlated with cfPWV values, and high serum OPG level is an independent marker of aortic artery stiffness in patients undergoing PD.
延伸閱讀
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