Lysophosphatidic acid (LPA) has been shown to be an important extra cellular signaling molecular in mammalian systems. It induces mitogenesis under certain stress. Autophagy is a catabolic membrane-trafficking phenomenon that occurs in response to dramatic changes in the nutrients available to yeast cells. It happens when cell cycles arrest contrary to LPA response. We hypothesize that LPA induces mitogenesis and inhibits autophagy in yeast. Our results indicate that LPA activates the mitogenesis but doesn't inhibit autophagy in yeast.