Voltage-gated sodium channels of peripheral nerve and pain: A review

周邊神經鈉離子通道與疼痛：綜說

謝介平(Ja-Ping Shieh) ； 褚錦承(Chin-Chen Chu) ； 林耀聰(Yao-Tsung Lin) ； 王志中(Jhi-Joung Wang)

《疼痛醫學雜誌》 27卷1期 (2017/03) Pp. 16-28

摘要

Voltage-gated sodium channels; Voltage-gated sodium channels (VGSCs), are crucial for initiating and propagating action potential in neurons, are distributed in dorsal root ganglia cells and involved in the formation of pain. Of the VGSC subtypes, Nav1 .7, Nav1.8, and Nav1.9 are preferentially expressed in the peripheral nervous system. These subtypes are known to be important for conducting nociceptive stimuli, and mutations in these channels are thought to be the underlying cause of a variety of heritable pain diseases. This brief review provides an overview of the current literature on the role of VGSCs in pain generation, and it summarizes recent study results.

關鍵字

Pain ； Voltage-gated sodium channels ； Neuropathic pain ； Inflammatory pain

並列摘要

電壓門控鈉離子通道(Voltage-gated sodium channels，VGSCs)在神經元動作電位的起始和傳導中起著關键作用，它們廣泛存在於背根神經節中，參與了疼痛的形成。電壓門控鈉離子通道類型中主要有Nav1.7，Nav1.8和Nav1.9存在於周邊神經系統。電壓門控鈉離子通道亞型對傷害性感受性刺激的傳導非常重要，也因為其通道亞型突變造成遺傳的疾病。本文簡要就痛覺相關電壓門控鈉離子通道對疼痛產生情況和近期研究的結果進行綜述。

並列關鍵字

疼痛 ； 電壓門控鈉離子通道 ； 神經病理性疼痛 ； 炎性疼痛