Multimodal analgesia (MMA) combines analgesics of multiple classes acting on distinct target sites through different strategies, including non-opiate analgesics (NSAIDs, acetaminophen, COX-2 inhibitors), α-2 agonists, epidural analgesia, local infiltration of analgesics, continuous peripheral nerve blockade, and so on. MMA improves postoperative pain control, subsequently improves patients' satisfaction and quality of recovery. It also reduces opioid requirements, hence reduces many opioid-related adverse effects, such as constipation, PONV, sedation and respiratory depression. According to these benefits, MMA is currently the recommended practice in most fast-track clinical care plans, and all Enhanced Recovery After Surgery (ERAS) guidelines advocate MMA as perioperative pain management whenever possible.