Quality of Life among Pulmonary Tuberculosis Patients under Treatment in Eastern Taiwan

台灣東部肺結核病患治療期間生活品質的變化

鐘威昇(Wei-Sheng Chung) ； 李其融(Chi-Rong Li) ； 廖翎聿(Lin-Yu Liao) ； 楊文達(Wen-Ta Yang)

《台灣公共衛生雜誌》 33卷1期 (2014/02) Pp. 23-35

https://doi.org/10.6288/TJPH201433102089

摘要

Objectives: We evaluate the quality of life (QOL) among tuberculosis (TB) patients during different treatment periods. Methods: We conducted a population based cohort study in Eastern Taiwan. The short version of the World Health Organization quality of life (WHOQOL) questionnaire was administered to TB patients under treatment at 3 periods: during an initial treatment period, at a 2-month treatment period, and after a 6-month treatment period. Results: 140 TB patients were interviewed after approval by institutional review boards and interviewee informed consents. The average age of the patients was 48.9 years (SD=18.9 years) and more than half of them were men. Physical domain scores decreased significantly from the initial treatment to the 2-month anti-TB treatment (12.517±2.832, 11.667±3.179, p＜.001), and then increased after a 6-month treatment (12.691±2.903). Social domain scores also significantly decreased from the initial treatment to the 2-month anti-TB treatment (13.618±2.685, 12.899±2.953, p＜.05), and then increased after 6 months of treatment (13.900±2.552).While controlling probable factors affecting the 4 domain scores related to QOL, drugs related hepatitis reduced physical (β=2.3700, p＜.001), psychological (β=2.633, p＜.001), social (β=4.135, p＜.001), and environmental domain scores (β=3.449, p＜.001) and blurred vision significantly reduced physical (β=2.290, p＜.001), psychological (β=2.127, p＜.001), social (β=1.075, p＜.05), and environmental domain scores (β=1.587, p＜.01). Physical domain scores significantly decreased as age increased per 10-year (β=0.39, p＜.01). The patients employed exhibited significantly higher scores of physical, social, and environmental domains compared than those who were unemployed (β=0.959, p＜.05, β=0.815, p＜.05, and β=0.852, p＜.05 respectively). The patients with a higher income showed fewer scores of psychological domain (β=2.029, p＜.01) compared than those who having a lower income. Conclusions: TB affected individual health and QOL, although patients underwent effective treatment. Healthcare workers should be concerned regarding the adverse reactions of anti-TB drugs.

關鍵字

生活品質 ； 肺結核病患 ； 副作用

並列摘要

Objectives: We evaluate the quality of life (QOL) among tuberculosis (TB) patients during different treatment periods. Methods: We conducted a population based cohort study in Eastern Taiwan. The short version of the World Health Organization quality of life (WHOQOL) questionnaire was administered to TB patients under treatment at 3 periods: during an initial treatment period, at a 2-month treatment period, and after a 6-month treatment period. Results: 140 TB patients were interviewed after approval by institutional review boards and interviewee informed consents. The average age of the patients was 48.9 years (SD=18.9 years) and more than half of them were men. Physical domain scores decreased significantly from the initial treatment to the 2-month anti-TB treatment (12.517±2.832, 11.667±3.179, p＜.001), and then increased after a 6-month treatment (12.691±2.903). Social domain scores also significantly decreased from the initial treatment to the 2-month anti-TB treatment (13.618±2.685, 12.899±2.953, p＜.05), and then increased after 6 months of treatment (13.900±2.552).While controlling probable factors affecting the 4 domain scores related to QOL, drugs related hepatitis reduced physical (β=2.3700, p＜.001), psychological (β=2.633, p＜.001), social (β=4.135, p＜.001), and environmental domain scores (β=3.449, p＜.001) and blurred vision significantly reduced physical (β=2.290, p＜.001), psychological (β=2.127, p＜.001), social (β=1.075, p＜.05), and environmental domain scores (β=1.587, p＜.01). Physical domain scores significantly decreased as age increased per 10-year (β=0.39, p＜.01). The patients employed exhibited significantly higher scores of physical, social, and environmental domains compared than those who were unemployed (β=0.959, p＜.05, β=0.815, p＜.05, and β=0.852, p＜.05 respectively). The patients with a higher income showed fewer scores of psychological domain (β=2.029, p＜.01) compared than those who having a lower income. Conclusions: TB affected individual health and QOL, although patients underwent effective treatment. Healthcare workers should be concerned regarding the adverse reactions of anti-TB drugs.

並列關鍵字

quality of life ； TB patients ； adverse reactions

參考文獻

Chung WS, Chang RE, Guo HR. Variations of care quality for infectious pulmonary tuberculosis in Taiwan: a population based cohort study. BMC Public Health 2007;7:107. doi:10.1186/1471-2458-7-107.

Lee JJ, Wu RL, Lee YS, Wu YC, Chiang CY. Treatment outcome of pulmonary tuberculosis in eastern Taiwan - experience at a medical center. J Formos Med Assoc 2007;106:25-30. doi:10.1016/ S0929-6646(09)60212-6.

Long NH, Johansson E, Diwan VK, Winkvist A. Fear and social isolation as consequences of tuberculosis in VietNam: a gender analysis. Health Policy 2001;58:69-81. doi:10.1016/S0168-8510(01)00143-9.

Abioye IA, Omotayo MO, Alakija W. Sociodemographic determinants of stigma among patients with pulmonary tuberculosis in Lagos, Nigeria. Afr Health Sci 2011;11(Suppl 1):S100-4. doi:10.4314/ ahs.v11i3.70078.

Christodoulou M. The stigma of tuberculosis. Lancet Infect Dis 2011;11:663-4. doi:10.1016/S1473- 3099(11)70228-6.