短期「高住低訓」訓練方式對單次運動後人體骨骼肌肉肝醣合成之影響

The Influence of Short-Term Normoxic Exercise Training and Recovery in Hypoxic Condition on Glycogen Synthesis in Exercised Human Skeletal Muscle

張嘉珍(Chia-Chen Chang) ； 廖淑芬(Su-Fen Liao) ； 張聖良(Sheng-Liang Chang) ； 程一雄(I-Shiung Cheng) ； 徐孟達(Mong-Da Hsu)

《體育學報》 47卷3期 (2014/09) Pp. 339-348

https://doi.org/10.6222/pej.4703.201409.1002

摘要

目的：探討短期「高住低訓」的訓練方式，是否能提高單次運動後人體肌肉肝醣合成能力。方法：八名健康且規律運動男性進行交叉實驗設計，排空期為二十一天。受試者隨機接受每天一小時70%最大攝氧量（VO_2max）訓練且常壓常氧環境睡眠共七天（控制實驗），或每天一小時運動訓練（70%VO_2max）且常壓低氧環境睡眠十小時（低氧實驗）共七天。兩種實驗皆在第八天進行單次一小時70%VO_2max腳踏車運動，隨後採集肌肉樣本，再給予補充高碳水化合物飲食，後續第四小時執行第二次肌肉採樣。血液樣本於單次運動前後、運動後四小時期間每三十分鐘採血。研究數據以重複量數雙因子變異數分析。結果：低氧實驗在運動後肌肉肝醣濃度顯著高於控制實驗（p ＜ .05）；低氧實驗的游離脂肪酸與甘油濃度在運動前、後與運動後三十分鐘顯著低於控制實驗（p ＜ .05）；兩種實驗的血漿葡萄糖、血漿葡萄糖曲線下面積、胰島素、胰島素曲線下面積、皮質醇濃度在不同時間點皆未達顯著差異。結論：短期高住低訓可能加速運動恢復初期的人體骨骼肌肉肝醣合成速率，提高人體對醣類的利用與儲存，具肝醣超補的作用。

關鍵字

運動訓練 ； 肌肉肝醣 ； 碳水化合物

並列摘要

Purpose: To investigate whether short-term normoxic exercise training and recovery in hypoxic condition could enhance the glycogen synthesis in human skeletal muscle. Method: In this cross-over designed study, eight healthy males were categorized into two trials. Subjects in first trial exercised at 70% VO_2max for 60 minutes per day and recovered at sea level (control), and subjects in second trial exercised at 70% VO_2max for 60 minutes per day at sea level and recovered in a hypoxic chamber (living high and training low, LHTL) for 7 days in random order. On 8th day, subjects in both trials performed a 60-min cycling exercise at 70% VO_2max, and subsequently consumed a high carbohydrate meal. Biopsied muscle samples were obtained from vastus lateralis immediately and 4 h after exercise. Blood samples were collected before exercise, immediately after exercise, and for every 30 min during 4-h post-exercise recovery. The same procedures were repeated after three weeks washout period. Result: Muscle glycogen level response at post-exercise 4 h markedly higher in LHTL than in control (p ＜ .05). Both of non-ester fatty acid and glycerol level were markedly lower before exercise, immediately after exercise, and 30 min during recovery period in LHTL compared to control (p ＜ .05). However, blood glucose, blood glucose area under curve, insulin, insulin area under curve, and cortisol levels were not altered between trails (p ＞ .05). Conclusion: LHTL could increase the rate of muscle glycogen synthesis immediately after a single bout of exercise and promote glucose uptake as result to enhance glycogen supercompensation in humans.

並列關鍵字

exercise training ； muscle glycogen ； carbohydrate

參考文獻

Beelen, M., Burke, L. M., Gibala, M. J., & van Loon, L. Jc. (2010). Nutritional strategies to promote postexercise recovery. International Journal of Sport Nutrition and Exercise Metabolism, 20(6), 515-532.

Birnbaum, M. J. (2001). Diabetes: Dialogue between muscle and fat. Nature, 409(8), 672-673.

Bonen, A., Luiken, J. J., Arumugam, Y., Glatz, J. F., & Tandon, N. N. (2000). Acute regulation of fatty acid uptake involves the cellular redistribution of fatty acid translocase. The Journal of Biological Chemistry, 275(19), 14501-14508.

Bouissou, P., Peronnet, F., Brisson, G., Helie, R., & Ledoux, M. (1986). Metabolic and endocrine responses to graded exercise under acute hypoxia. European Journal of Applied Physiology and Occupational Physiology, 55(3), 290-294.

Braun, B. (2008). Effects of high altitude on substrate use and metabolic economy: Cause and effects? Medicine and Science in Sports and Exercise, 40(8), 1495-1500.