Sleep and epilepsy have a reciprocal relationship. Good quantity and quality sleep is required for memory consolidation and synaptic plasticity. Epilepsy can worsen sleep architecture and severity of sleep disorders. Antiepileptic drugs (AEDs) that are commonly used for seizure treatment affect sleep quality and architecture. It is important for clinicians to understand the proclivity of a specific AED to affect the quality of sleep in order to guide epilepsy therapy.