間斷投予副甲狀腺素對於骨組織的合成代謝作用

Anabolic Effect of Intermittent Parathyroid Hormone on Bone

陳青青(Ching-Ching Chen) ； 賴玉玲(Yu-Lin Lai) ； 陳恆理(Hen-Li Chen)

《中華民國牙周病醫學會雜誌》 12卷4期 (2007/12) Pp. 337-344

摘要

副甲狀腺素是調節血鈣平衡的重要荷爾蒙，一直以來醫學上認爲此荷爾蒙爲了增加血鈣濃度而分解骨組織，造成骨的異化代謝作用。然而，30年代已經有動物實驗發現，間斷地注射副甲狀腺萃取物，有助於骨密度的增加。近年來，醫學界已經將人工合成之副甲狀腺素，成功用於嚴重骨質疏鬆症病人之治療，明顯得到增加骨質密度及降低骨折機率之結果。而牙科醫師也期待在骨質條件不好的病人，經由副甲狀腺素治療，對於局部骨再生及癒合（例如：顱顏骨缺損、牙周骨缺損、顎骨骨折、植體周圍骨整合等），有促進合成代謝作用，進而提高臨床治療的成功率。

關鍵字

副甲狀腺素 ； 合成代謝作用 ； 間斷投予

並列摘要

Parathyroid hormone plays an important role in calcium homeostasis. PTH is generally considered as a catabolic agent that promotes bone resorption. During 1930's, animal study has demonstrated promotion of bone formation by daily injection of parathyroid extract. The anabolic effect of PTH has been proved and used in treating osteoporosis now. In addition, increasing evidence suggest that PTH are beneficial in fracture healing process and implant placement. However, the effect of intermittent PTH in osseous defect, such as periodontal bony destruction or ridge defect, has not been determined. The PTH effect in osseous defect regeneration warrants further studies.

並列關鍵字

parathyroid hormone ； anabolic effect ； intermittent