免疫療法在非癌症皮膚疾病之應用

Use of Immunotherapy in Non-Neoplastic Skin Diseases

蔡呈芳(Tsen-Fang Tsai)

《台灣醫學》 22卷4期 (2018/07) Pp. 394-404

https://doi.org/10.6320/FJM.201807_22(4).0006

摘要

免疫療法的進展，尤其是生物製劑的出現，讓許多皮膚病有了突破性的治療進展。乾癬就是其中的先行者，目前已有五代不同機轉的生物製劑被核准。除了第一代的alefacept及efalizumab，其他的生物製劑都仍在臨床使用中，作用於腫瘤壞死因子、介白素12/23、介白素17、介白素23。由於高度療效及相對良好的安全性，此類產品成為了中重度乾癬患者的黃金治療準則，除乾癬外，dupilumab也剛被核准用於異位性皮膚炎，這是一種介白素4/13的抑制劑，而IgE抑制劑omalizumab及adalimnmab則分別核准於慢性自發性蕁麻疹及化膿性汗腺炎。最近rituximab則在美國核准用於尋常性天疱瘡。生物製劑雖然療效佳，相對風險低，但是高昂的費用讓多數需要的患者無法負擔，健保基於財政負擔更無法全面給付。期待當這些藥品專利過期後，價格下降，能讓更多需要的患者可使用。也期待免疫學的進展，能夠繼續發現新的藥物及作用機轉，解決更多的皮膚疾病。

關鍵字

乾癬 ； 異位性皮膚炎 ； 化膿性汗腺炎 ； 天疱瘡 ； 生物製劑

並列摘要

Advancement in immunotherapy, especially biologic agents, has revolutionized the treatment of many skin diseases. Psoriasis is at the forefront of this treatment paradigm change. Five generations of biologics have been approved for use in psoriasis. Except for the first generation (alefacept, efalizumab), all the other biologics are still in clinical use targeting tumor necrosis factor, interleukin 12/23, interleukin 17 and interleukin 23. Due to their high efficacy and favorable safety profiles, these biologics have become the gold standard in the treatment of moderate to severe psoriasis. Biologics have also been approved for atopic dermatitis, but only dupilumab, an interleukin 4/13 dual inhibitor, has recently been approved. However, the efficacy seems to lag behind that in psoriasis, and topical corticosteroid is often used concomitantly, which reflects the complexity in atopic dermatitis pathogenesis. For the other immune based skin disease, adalimumab is approved for hidradenitis suppurativa, omalizumab for chronic idiopathic urticaria and rituximab for pemphigus vulgaris (in United states). Despite the high efficacy and relative safety of these biologics, the high costs of these agents limit the accessibility to most patients, an important issue which hopefully can be resolved after the patents expire. Also, we hope more unsolved skin diseases can be better managed with the approval of novel agents and understanding of their pathogenesis.

並列關鍵字

psoriasis ； atopic dermatitis ； hidradenitis suppurativa ； pemphigus ； biologics

參考文獻

Ellis CN, Krueger GG: Treatment of chronic plaque psoriasis by selective targeting of memory effector T lymphocytes. N Engl J Med 2001;345:248-55. doi: 10.1056/NEJM200107263450403

Huang PH, Liao YH, Wei CC, et al: Clinical effectiveness and safety experience with alefacept in the treatment of patients with moderate-to-severe chronic plaque psoriasis in Taiwan: results of an open-label, single-arm, multicentre pilot study. J Eur Acad Dermatol Venereol 2008;22:923-30. doi: 10.1111/j.1468-3083.2007.02575.x

Gordon KB, Papp KA, Hamilton TK, et al: Efalizumab for patients with moderate to severe plaque psoriasis: a randomized controlled trial. JAMA 2003;290:3073-80. doi: 10.1001/jama.290.23.3073

Tsai TF, Liu MT, Liao YH, et al: Clinical effectiveness and safety experience with efalizumab in the treatment of patients with moderate-to-severe plaque psoriasis in Taiwan: results of an open-label, single-arm pilot study. J Eur Acad Dermatol Venereol 2008;22:345-52. doi: 10.1111/j.1468-3083.2007.02430.x

Seminara NM, Gelfand JM: Assessing long-term drug safety: lessons (re) learned from raptiva. Semin Cutan Med Surg 2010;29:16-9. doi: 10.1016/j.sder.2010.01.001