再談減除白血球血小板的好處

研究顯示輸注減除白血球血小板（減白血小板）可有效降低非溶血性發熱性輸血不良反應、巨細胞病毒感染及預防血小板輸注無效的發生，足以提昇輸血安全。此外，研究評估使用減白血小板可减少輸血不良反應的處置費用，更可以大幅降低因血小板輸注無效導致的血品費用。是以呼籲在台灣應放寬或解除輸用減白血小板的限制，以創造雙贏的局面。

關鍵字

減除白血球血小板；輸血不良反應；巨細胞病毒；非溶血性發熱性輸血反應；血小板輸注無效

並列摘要

Substantial reports showed the evidenced-based effect of transfusion of leuko-reduced platelet concentrates (LRPC) including reduction of non-hemolytic febrile transfusion adverse reaction (NHFTR), CMV infection and prevention of occurrence of platelet transfusion refractoriness. Therefore, LRPC rather than platelet concentrates can improve transfusion safety definitely. Cost evaluation revealed that using LRPC can reduce total fee in dealing with NHFTR. In addition, another study showed that transfusion of LRPC can decrease the cost of management of platelet transfusion refractoriness dramatically. In this moment, we call for releasing or completely eliminating the limitation on the use of LRPC to create a win-win situation in Taiwan.

並列關鍵字

leukocyte-reduced platelets ； transfusion reaction ； cytomegalovirus ； non-hemolytic febrile transfusion reactions ； platelet transfusion refractoriness

參考文獻

林東燦、羅仕錡：減除白血球血品的實證醫學。台灣醫學2018;22:199-204。[Evidence-Based Medicine of Leukocyte-reduced Blood Components]

Lu SC, Chin LT, Wu FM, et al: Seroprevalence of CMV antibodies in a blood donor population and premature neonates in the south-central Taiwan. Kaohsiung J Med Sci 1999;15:603-10.

Bate SL, Dollard SC, Cannon MJ：Cytomegalovirus seroprevalence in the United States: the national health and nutrition examination surveys, 1988-2004. Clin Infect Dis 2010;50:1439-47

Vivek Bhat, Amit Joshi, Rahul Sarode, et al: Cytomegalovirus infection in bone marrow transplant patient. World J Transplant 2015;5: 287-91.

Heddle NM：Pathophysiology of febrile non-hemolytic transfusion reactions. Curr Opin Hematol 1999;6:420-6.

國際替代計量

再談減除白血球血小板的好處

全文下載

主題瀏覽