Decreased Serum S100A10 Levels in Patients with Both Schizophrenia and Metabolic Syndrome

Chin-Chuen Lin ； Meng-Chang Tsai ； Tiao-Lai Huang

《台灣精神醫學》 34卷3期 (2020/09) Pp. 110-114

https://doi.org/10.4103/TPSY.TPSY_28_20

摘要

Background: Brain-derived neurotrophic factor (BDNF) is involved in the pathophysiology of schizophrenia and metabolic syndrome. S100A10 is associated with the antidepressant effect of BDNF, and decreased S100A10 mRNA has also been found in schizophrenia. S100A10 also interacts with serotonin and annexin A2, both are associated with obesity. In this study, we intended to investigate the serum BDNF and S100A10 levels in patients with schizophrenia with and without metabolic syndrome. Methods: We recruited patients with schizophrenia, collected their demographic data, and measured their metabolic profiles, serum BDNF, and S100A10 levels. Clinical symptoms were evaluated using the Positive and Negative Syndrome Scale. Metabolic syndrome was determined using the criteria provided by the Ministry of Health and Welfare of Taiwan. Results: In this study, 38.7% of 93 participants had metabolic syndrome. No statistical significance was found in serum BDNF levels between patients with and without metabolic syndrome. Patients with metabolic syndrome had significantly lower S100A10 levels compared to those without (p ＜ 0.01). Conclusion: Decreased serum S100A10 levels were found in patients with schizophrenia and metabolic syndrome compared to schizophrenic patients without. Those data suggested that serum S100A10 level could play a rôle in metabolic syndrome among patients with schizophrenia.

關鍵字

brain-derived neurotrophic factor ； energy metabolism ； p11 ； positive and negative syndrome scale

參考文獻

Grewal T, Enrich C, Rentero C, et al.: Annexins in adipose tissue: novel players in obesity. Int J Mol Sci 2019;20:3449. doi: 10.3390/ ijms20143449.

Lewin GR, Barde YA: Physiology of the neurotrophins. Annu Rev Neurosci 1996; 19: 289-317.

Thompson Ray M, Weickert CS, Wyatt E, et al.: Decreased BDNF, trk-BTK+ and GAD67 mRNA expression in the hippocampus of individuals with schizophrenia and mood disorders. J Psychiatry Neurosci 2011; 36: 195-203.

Svenningsson P, Greengard P: p11 (S100A10) – an inducible adaptor protein that modulates neuronal functions. Curr Opin Pharmacol 2007; 7: 27-32.

Warner-Schmidt JL, Chen EY, Zhang X, et al.: A role for p11 in the antidepressant action of brain-derived neurotrophic factor. Biol Psychiatry 2010; 68: 528-35.