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運動測試對第2型糖尿病患之血糖、血漿中的硝酸鹽/亞硝酸鹽與血管傳導性的影響

Vascular Conductivity, Blood Glucose and Plasma Nitrate/Nitrite Response to Exercise Testing in Type 2 Diabetic Mellitus

摘要


Background and Purpose: Patients with type 2 diabetes without cardiovascular disease have a reduced exercise capacity compared with nondiabetic subjects. To assesse the impacts of acute exercise on glycemic control, vascular and plasma nitrate/nitrite reaction in type 2 diabetes mellitus (DM) patients. Methods: A total of 46 patients with type 2 DM and 13 control subjects with age, height and weight matched were studied. Based on the HbAIc levels, the DM patients were further divided into two subgroups: poor DM control (PDM, glycosylated hemoglobin (HbAlc≥8.0%) and good DM control (GDM, HbA1c<8.0%). All patients underwent an incremental exercise test until they exceeded their 90% age-predicated maximal heart rate. Electrocardiogram (ECG) and blood pressure were measured during exercise. The vascular conductivity, plasma nitrate/nitrite and glucose concentration were measured before and immediately after exercise. Results: After exercise, the venous outflow, venous tone, and venous capacity significantly decreased from resting (p<0.05); However, the venous resistance significantly increased from resting in all groups (p<0.05). The pairwise comparisons revealed that the patients in the PDM group had lower levels of rest arterial inflow, venous outflow and venous capacity than the GDM group (p<0.05). Those in the control group had the largest hyperemic arterial inflow among all groups (p<0.05). Furthermore, the postprandial glucose level was significantly decreased and the plasma nitrate/nitrite level was increased significantly after exercise in the control group (p<0.05) only, but unchanged in two diabetic subgroups. Conclusion: Poor metabolic control (HbAlc≥8.0%) may cause impairment of vascular regulation and glucose utilization during exercise testing.

並列摘要


Background and Purpose: Patients with type 2 diabetes without cardiovascular disease have a reduced exercise capacity compared with nondiabetic subjects. To assesse the impacts of acute exercise on glycemic control, vascular and plasma nitrate/nitrite reaction in type 2 diabetes mellitus (DM) patients. Methods: A total of 46 patients with type 2 DM and 13 control subjects with age, height and weight matched were studied. Based on the HbAIc levels, the DM patients were further divided into two subgroups: poor DM control (PDM, glycosylated hemoglobin (HbAlc≥8.0%) and good DM control (GDM, HbA1c<8.0%). All patients underwent an incremental exercise test until they exceeded their 90% age-predicated maximal heart rate. Electrocardiogram (ECG) and blood pressure were measured during exercise. The vascular conductivity, plasma nitrate/nitrite and glucose concentration were measured before and immediately after exercise. Results: After exercise, the venous outflow, venous tone, and venous capacity significantly decreased from resting (p<0.05); However, the venous resistance significantly increased from resting in all groups (p<0.05). The pairwise comparisons revealed that the patients in the PDM group had lower levels of rest arterial inflow, venous outflow and venous capacity than the GDM group (p<0.05). Those in the control group had the largest hyperemic arterial inflow among all groups (p<0.05). Furthermore, the postprandial glucose level was significantly decreased and the plasma nitrate/nitrite level was increased significantly after exercise in the control group (p<0.05) only, but unchanged in two diabetic subgroups. Conclusion: Poor metabolic control (HbAlc≥8.0%) may cause impairment of vascular regulation and glucose utilization during exercise testing.

被引用紀錄


林玉梅(2013)。東台灣治療成功之結核病患健康促進生活型態及其相關因素之研究〔碩士論文,國立臺灣師範大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0021-0801201418035011

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