Final Height of Turner Syndrome Patients Treated With Growth Hormone After 6 Years of Age-Experience of One Medical Center

Yu-Mei Wang ； Yu-Jun Chang

《The Changhua Journal of Medicine》 17卷4期 (2019/12) Pp. 166-172

https://doi.org/10.6501/CJM.201912_17(4).0003

摘要

Growth hormone (GH) treatment improves growth and final height (FH) in girls with Turner syndrome (TS). This study evaluated the growth outcome after GH therapy in patients with TS above 6 years of age. Twenty-eight girls with TS received daily injections of GH at a fixed dosage of 0.33 mg/kg/week at the median chronological age of 8.5 years for a median duration of 6.75 years. Multiple gamma regression models were used to assess factors associated with FH. The median FH was 151.2 cm, and the height gain over the projected adult height was 5.95 cm. The median growth velocity (GV) in the first year was 7.70 cm, significantly higher than that in the second (6.0 cm) and third years (5.20 cm) (p ＜ 0.001). The median height change was 1.05 standard deviation score (SDS) and the median gain in Turner height SDS was 1.82 after GH treatment. FH was significantly correlated with the karyotype, duration of treatment, initial height, GV in the first and third years, and age at estrogen replacement therapy initiation. GH therapy was effective in patients with TS aged 6 years and older, regardless of patient age at the beginning of therapy. However, the karyotype may influence the effect of GH treatment and FH.

關鍵字

final height ； GH treatment ； Turner syndrome