This study was designed to examine the role and effect of TV series in the cultural creative industries from audience perspective, and "Guardian: The lonely and the great god" was adopted as an example. Cultural Creative Design Program Evaluation was adopted as the research framework to develop a questionnaire. Data was collected from Sep. 17th to Sep. 29th, 2017 with snowball sampling method. A total of 264 valid questionnaires were collected. The results showed that the participants felt the script with regional feature and creativity is one of the reasons why the TV series are popular. In addition, some other factors, such as casting, actor acting, and production quality should be work together to make the drama series successful. Furthermore, these TV series brought a lot of economic benefits even though those benefits may not come from their derivative products.