Association Between Benign Prostatic Hyperplasia and Lumbar Spine Bone Mineral Density

Background: Few studies have explored the relationship between benign prostatic hyperplasia (BPH) and bone mineral density (BMD). This retrospective study aims to investigate the relationship between BPH and BMD. Methods: Male patients who underwent a general health examination from June 2014 to December 2017 at a regional hospital in southern Taiwan were eligible for this study. Those with a history of spinal surgery, total hip replacement, use of anti-osteoporosis or anti-BPH medications, and those without complete medical histories were excluded. In the final cohort of 1997 patients, BMD and prostate size were estimated by dual-energy X-ray absorptiometry and ultrasonography, respectively, and subjects were divided into normal and BPH groups based on prostate size. BMD and T-scores were compared between the normal and BPH groups. Results: The mean BMD and lumbar spine T-scores but not hip T-scores were significantly higher in patients with BPH than in those with normal prostate size. Conclusions: Our results suggest that for males with elevated lumbar spine BMD but normal hip BMD and hip T-scores, the possibility of an enlarged prostate should be considered. Further clinical evaluation of such individuals for asymptomatic prostate enlargement is recommended.

關鍵字

benign prostatic hyperplasia ； bone mineral density ； lumbar spine

並列摘要

背景：目前少有研究探討良性攝護腺增生與骨質密度之間的關係，本篇研究為回溯性研究探討良性攝護腺增生和骨質密度之間的關係。方法：自2014年6月至2017年12月在臺灣南部地區醫院接受一般健康檢查的男性患者符合這項研究的條件。排除有脊柱外科手術史，全髖關節置換術，使用抗骨質疏鬆症或抗良性攝護腺增生藥物的患者以及沒有完整病史的患者被排除在外。最後總收集1,997位患者中，分別通過雙能X射線吸收法和超音波檢查來估計骨質密度和攝護腺大小，並根據攝護腺大小將受試者分為正常和良性攝護腺增生組。比較正常和良性攝護腺增生組之骨質密度和T評分。結果：良性攝護腺增生患者的平均骨質密度和腰椎T分數與正常組T分數有顯著高於正常前列腺大小的患者。結論：我們的研究結果發現，對於腰椎骨質密度較高但髖部骨質密度和髖部T分數正常的男性，應考慮前列腺肥大之可能性。建議對此類個案進行無症狀前列腺增大的進一步臨床評估。

並列關鍵字

良性前列腺肥大；骨質密度；腰椎

國際替代計量

Association Between Benign Prostatic Hyperplasia and Lumbar Spine Bone Mineral Density

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