螢光金奈米量子點合成及環境檢測與生物醫學之應用

螢光奈米材料為近年來的熱門材料之一，其中金奈米量子點（gold nanodots, Au NDs）由於製備容易、穩定性高、生物相容性佳、具有特殊光學性質等優點，因而在環境檢測及生醫應用等方面有極大發展。本文將主要著重於Au NDs的發光原理、合成步驟及應用開發。除了介紹AuNDs是由3-nm金奈米粒子（gold nanoparticle, Au NPs），搭配上硫醇分子（thiol ligands）的蝕刻（etching）作用及鍵結在金奈米粒子表面，所形成大小約2 nm的球型發光材料，同時分析形成的Au NDs光學性質，其放光特性與中心金屬核（core）大小與晶格及表面官能基與金離子形成錯合物（complex）的殼（shell）皆有很大的相關性。另外，當改變Au NDs表面的分子，可使AuNDs具有不同的功能性。藉而開發出各種感測器，可用於偵測重金屬離子、陰離子、生物小分子、蛋白質等，並實際應用於真實環境和生物樣品中。

關鍵字

螢光；金奈米量子點；表面官能基；環境檢測；生物醫學應用

並列摘要

Gold nanodots (Au NDs) have become one of the most popular materials for sensing of analytes in environmental and biological samples due to their ease of preparation, high stability, biocompatibility, and unique optical properties. The particle size of Au NDs are around 2 nm, at that size they attain special optical properties, such as photoluminescence due to quantum confinement effect. The surface ligands, the core-shell structure and size of Au NDs play important role in deciding the Au NDs' optical properties. Therefore, to control the size, surface functional groups and optical properties, the choice of synthesis method is highly important. Various synthesis methods including etching of larger gold nanoparticles by a suitable agent or by controlling the particle size during synthesis from gold solutions with thiol compounds have been reported. Moreover, the type of interaction between Au NDs and ligands is also important for sensing applications. In this mini-review, we mainly discuss the development of synthetic strategies, optical properties and application of Au NDs for sensing of metal ions, anions, small molecules and proteins.

並列關鍵字

Fluorescence ； Gold nanodots ； Surface ligands ； Environmental sensing ； Biomedical application

國際替代計量

螢光金奈米量子點合成及環境檢測與生物醫學之應用

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