鄰苯二酚類神經傳導物質之受體的合成研究

Toward the Syntheses of Molecular Receptors for Catechol-Related Neurotransmitters

施智文(Chih-Wen Shih)

指導教授 ： 邱勝賢

國立臺灣大學/理學院/化學研究所/碩士(2004年)

https://doi.org/10.6342/NTU.2004.00656

摘要

鄰苯二酚類的化合物如多巴胺(dopamine)、正腎上腺素(norepinephrine)等，已被證實為重要的神經傳導物質。目前已知精神分裂症與腦部多巴胺分泌過多有關，而憂鬱症則是由於正腎上腺素分泌不足所致，多年來群醫苦無對策的帕金森氏症亦是由於神經突觸所釋放的多巴胺不足所導致。從文獻上得知以二苯甘脲(diphenylglycoluril)為基本組成的分子夾可以鍵結鄰苯二酚類的分子，若能以此分子夾為基礎連接配合可以錯合銨離子的冠醚分子來建構一個新型的環狀分子，則此分子將可成為多巴胺類神經傳導物質的良好受體，有利後續從事神經傳導方面的研究。

關鍵字

神經傳導物質 ； 鄰苯二酚 ； 多巴胺

並列摘要

Some catechol-related compounds such as dopamine and norepinephrine are reported to be very important neurotransmitters. It is well known that schizophrenia, melancholia and Parkinson's disease all related the abnormally releasing of these neurotransmitters in brain. Since the molecular clips composed by diphenylglycoluril units are reported to be good catechol binders. We plan to build new molecular clips by linking diphenylglycoluril motif with crown ethers and use them as receptor molecules to detect dopamine-related neurotransmitters.

並列關鍵字

catechol ； dopamine ； neurotransmitter

參考文獻

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