可重複調控表面化學及區域特性之氣相鍍膜

Functionalized Poly-para-xylylene Coating with Chemically and Topographically Erasable Properties

何翠蘋(Cuei-Ping Ho)

指導教授 ： 陳賢燁

國立臺灣大學/工學院/化學工程學研究所/碩士(2019年)

https://doi.org/10.6342/NTU201900330

摘要

薄膜製程技術已廣泛應用於半導體產業及生物醫學植入材料，受鍍膜保護的表面不僅能提升其基材穩定性，更能透過化學改質技術創造多樣之相關應用。然而，愈趨精密的感測裝置與複雜的生物系統，需要更靈活的表面反應性來達到即時、精準的反饋。本研究製備一可重複調控表面化學及區域特性之薄膜，以達到靈活的界面性質。此表面改質技術不僅能於特定區域鍵結功能性分子，更能任意操控化學鍵之斷裂與生成，清除並重新鍵結另一功能性分子於欲表現之區域。利用化學氣相沈積形成聚對二甲苯的主鏈結構和二硫烷基丙酸的側鏈官能基的高分子薄膜，能夠塗覆於各式各樣的基材，其中二硫烷基丙酸官能基提供了以下功能：（1）透過羧基多樣的反應性（如：偶聯反應、酯化反應）鍵結功能性分子，此外（2）藉由雙硫鍵的斷鍵反應去除（1）所鍵結的分子同時形成具高度化學活性的硫醇基，（3）和尾端帶有硫醇基之新的功能性分子重新生成雙硫鍵，藉此達到可重複控制化學特性於特定幾何區域之表面性質。實驗中，利用螢光圖樣視覺化此操控技術。最後更成功應用於表面濕潤性的控制，創造出多種親水/疏水區域圖樣於同一表面，並完成親水/疏水交替循環。

關鍵字

可重複調控 ； 表面改質 ； 功能性聚對二甲苯 ； 區域表面改質

並列摘要

Coating technology has been widely applied to semi-conductor industry and biomedical implants and has provided long-term stability and further modification for several decades. However, the surface modification was not dynamic enough to satisfy the external stimuli response and sophisticated biological system. Herein, in this study, an erasable coating was synthesized to perform surface modification of rendering a precise and yet flexible interface property and was able to provide defined and confined surface chemistry/function, and moreover, was able to erase such installed chemistry/function in a time scale or location of interests; or in addition, with the accessibility to reconnect the interface to a new chemistry/function. The coating was composed of a backbone structure of poly-para-xylylene and a side chain functionality of disulfanyl propanoic acid, and the coating was prepared via a vapor-phased polymerization/deposition process featuring a well-known advantage of being conformal to the coated substrates and was able to apply the coating with regardless of the substrate materials. The functionality of disulfanyl propanoic acid of the coating provides rationale capability to (i) access specific conjugation through the carboxyl group, (ii) erase the already-installed chemistry/function from (i) via the integrated disulfide load-lock moiety and in a controlled and confined manner, and (iii) reactivate the surface property to a second divergent chemistry/function via the additional feature of using the disulfide interchange reaction. The important and unique capability of erasable coating to control interface properties was showed by fluorescent immobilization. In addition, based on using the coating technology, the modification of a surface was demonstrated with the creation of a hybrid presentation and a geographically-defined hydrophilic/hydrophobic wetting property on the same surface, as well as a programmed control of alternating the wetting property between the hydrophilic and hydrophobic state in two complete cycles was shown.

並列關鍵字

erasable properties ； surface modification ； functionalized poly p-xylylene ； surface patterns

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