- 期刊
Lifetime Overproduction of Circulating Angiotensin-(1-7) in Rats Attenuates the Increase in Skeletal Muscle Damage Biomarkers after Exhaustive Exercise
摘要
Angiotensin-(1-7) (Ang-[1-7]) can modulate glucose metabolism and protect against muscular damage. The aim of this study was to investigate the influence of lifetime increase of circulating levels of Ang-(1-7) at exhaustive swimming exercise (ESE). Sprague-Dawley (SD) and transgenic rats TGR(A1-7)3292 (TR) which overproduce Ang-(1-7) (2.5-fold increase) were submitted to ESE. The data showed no differences in time to exhaustion (SD: 4.90 ± 1.37 h vs. TR: 5.15 ± 1.15 h), creatine kinase, and transforming growth factor beta (TGF-β). Lactate dehydrogenase (SD: 219.9 ± 12.04 U/L vs. TR: 143.9 ± 35.21 U/L) and α-actinin (SD: 336.7 ± 104.5 U/L vs. TR: 224.6 ± 82.45 U/L) values were significantly lower in TR. There was a significant decrease in the range of blood glucose levels (SD: -41.4 ± 28.32 mg/dl vs. TR: -13.08 ± 39.63 mg/dl) in SD rats. Muscle (SD: 0.06 ± 0.02 mg/g vs. TR: 0.13 ± 0.01 mg/g) and hepatic glycogen (SD: 0.66 ± 0.36 mg/g vs. TG: 2.24 ± 1.85 mg/g) in TR were higher. The TR presented attenuation of the increase in skeletal muscle damage biomarkers and of the changes in glucose metabolism after ESE.
參考文獻
延伸閱讀
- Burdzinska, A., Gala, K., Kowalewski, C., Zagozdzon, R., Gajewski, Z., & Pdczek, L. (2014). Dynamics of Acute Local Inflammatory Response after Autologous Transplantation of Muscle-Derived Cells into the Skeletal Muscle. Mediators of Inflammation, (2014-5), 7-18. https://doi.org/10.1155/2014/482352
- Lin, Y. A., Khamoui, A. V., Liao, C. C., Huang, C. C., & Hsu, M. C. (2015). Improvement of Exercise Performance and Attenuation of a Marker of Muscle Damage by Epimedium Brevicornum Supplementation in Mice. Adaptive Medicine, 7(2), 97-105. https://doi.org/10.4247/AM.2015.ABF111
- Huang, C. C., Lin, T. J., Lu, Y. F., Chen, C. C., Huang, C. Y., & Lin, W. T. (2009). Protective Effects of L-Arginine Supplementation against Exhaustive Exercise-Induced Oxidative Stress in Young Rat Tissues. The Chinese Journal of Physiology, 52(5), 306-315. https://doi.org/10.4077/CJP.2009.AMH068
- Bilski, J., Bialy, A. I. M., Brzozowski, B., Magierowski, M., Jasnos, K., Maczka, G. K., Urbanczyk, K., Belowska, A. P., Wcislo, M. Z., Mach, T., & Brzozowski, T. (2015). Moderate Exercise Training Attenuates the Severity of Experimental Rodent Colitis: The Importance of Crosstalk between Adipose Tissue and Skeletal Muscles. Mediators of Inflammation, 2015(), 73-84-307. https://doi.org/10.1155/2015/605071
- Chen, H. I., Cheng, S. Y., & Jen, C. J. (1999). Chronic Exercise Enhances Vascular Responses to Clonidine in Rats by Increasing Endothelial α2-Adrenergic Receptor Affinity. The Chinese Journal of Physiology, 42(2), 61-66. https://www.airitilibrary.com/Article/Detail?DocID=03044920-199906-42-2-61-66-a