Effect of Trigonella foenum-graecum (Fenugreek) Extract on Blood Glucose, Blood Lipid and Hemorheological Properties in Streptozotocin-Induced Diabetic Rats
Wan-Li Xue；Xuan-She Li；Jian Zhang；Yong-Hui Liu；Zhi-Lun Wang；Rui-Juan Zhang
diabetes ； Trigonella foenum-graecum ； fenugreek ； blood glucose ； blood lipid ； hemorheology
Asia Pacific Journal of Clinical Nutrition
|Volume or Term/Year and Month of Publication||
16卷S1期（2007 / 04 / 01）
422 - 426
Trigonella foenum-graecum (fenugreek) seeds have previously been shown to have hypoglycemic and hypocholesterolemic effects on type 1 and type 2 diabetes mellitus patients and experimental diabetic animals. The Trigonella foenum-graecum extract has now been investigated for its effects on general properties, blood glucose and blood lipid, and hemorheological parameters in experimental diabetic rats. Streptozotocin-induced diabetic rats were administrated by oral intragastric intubation separately with low dose (0.44 g/kg.d), middle dose (0.87 g/kg.d), high dose (1.74 g/kg.d) of Trigonella foenum-graecum extract, and Metformin HCl (0.175 g/kg.d) for 6 weeks. Compared with diabetic group, rats treated with Trigonella foenum-graecum extract had an increase in body weight and a decrease in kidney /body weight ratio (p＜0.05). Compared with diabetic group, rats treated Trigonella foenum-graecum extract had lower blood glucose, glycated hemoglobin, triglycerides, total cholestrol and higher higher-density-lipoprotein-cholesterol in a dose-dependent manner (p＜0.05). The plasma viscosity, whole blood viscosity of high shear rate (200 s^(-1)) and low shear rate (40 s^(-1)), erythrocyte sedimentation rate, whole blood reduction viscosity and platelet conglutination were significantly reduced in diabetic rats treated with high and middle doses of Trigonella foenum-graecum extract, but not in those treated with low dose of Trigonella foenum-graecum extract. It may be concluded that Trigonella foenum-graecum extract can lower kidney/body weight ratio, blood glucose, blood lipid levels and improve hemorheological properties in experimental diabetic rats following repeated treatment for 6 weeks.