Calcium Supplementation for 2 Years Improves Bone Mineral Accretion and Lean Body Mass in Chinese Adolescents

钙剂补充兩年改善中国青少年骨量沉积和瘦体重

Jing Yin ； Qian Zhang ； Ai-Ling Liu ； Wei-Jing Du ； Xiao-Yan Wang ； Xiao-Qi Hu ； Guan-Sheng Ma

《Asia Pacific Journal of Clinical Nutrition》 19卷2期 (2010/05) Pp. 152-160

https://doi.org/10.6133/apjcn.2010.19.2.01

摘要

Objective: to study the effects of different doses of calcium intake on bone health and body composition in Chinese adolescents. Methods: a double-blind randomized controlled trial of calcium carbonate supplementation in 257 healthy adolescents aged 12-15 years old for 24 months. Subjects were randomly assigned to four groups receiving chewable calcium carbonate tablets providing elemental calcium at 63 mg/d, 354 mg/d, 660 mg/d, 966 mg/d, respectively. At the end of intervention, we reclassified 197 adolescents into 3 groups who had received actual doses of elemental calcium of 85 mg/d (Low dose), 230 mg/d (Medium dose) and 500 mg/d (High dose). We measured bone mineral content (BMC), bone mineral density (BMD) and body composition by dual-energy X-ray absorptiometry. Results: BMC and BMD of total body and lumbar spine were increased significantly in both males and females after intervention at all doses (p＜0.05). In males, after supplementation, total body BMC in the medium and high dose groups (2464 g and 2437 g, respectively) was significantly higher than that in the low dose group (2321 g) after adjusting for age, pubertal development, BMI, physical activity and energy intake; in addition, lean body mass in the medium and high dose groups (49.1 kg and 48.8 kg, respectively) was significantly higher than that in the low dose group (46.7 kg) (p＜0.05). There was no significant effect of calcium supplementation on bone mass or body composition in females. Conclusions: calcium supplementation more than 230 mg/d for two years can improve bone mineral accretion and lean body mass in Chinese male adolescents.

關鍵字

青少年 ； 骨量沉积 ； 钙剂补充 ； 体成分 ； 中国

並列摘要

Objective: to study the effects of different doses of calcium intake on bone health and body composition in Chinese adolescents. Methods: a double-blind randomized controlled trial of calcium carbonate supplementation in 257 healthy adolescents aged 12-15 years old for 24 months. Subjects were randomly assigned to four groups receiving chewable calcium carbonate tablets providing elemental calcium at 63 mg/d, 354 mg/d, 660 mg/d, 966 mg/d, respectively. At the end of intervention, we reclassified 197 adolescents into 3 groups who had received actual doses of elemental calcium of 85 mg/d (Low dose), 230 mg/d (Medium dose) and 500 mg/d (High dose). We measured bone mineral content (BMC), bone mineral density (BMD) and body composition by dual-energy X-ray absorptiometry. Results: BMC and BMD of total body and lumbar spine were increased significantly in both males and females after intervention at all doses (p＜0.05). In males, after supplementation, total body BMC in the medium and high dose groups (2464 g and 2437 g, respectively) was significantly higher than that in the low dose group (2321 g) after adjusting for age, pubertal development, BMI, physical activity and energy intake; in addition, lean body mass in the medium and high dose groups (49.1 kg and 48.8 kg, respectively) was significantly higher than that in the low dose group (46.7 kg) (p＜0.05). There was no significant effect of calcium supplementation on bone mass or body composition in females. Conclusions: calcium supplementation more than 230 mg/d for two years can improve bone mineral accretion and lean body mass in Chinese male adolescents.

並列關鍵字

adolescents ； bone mineral accretion ； calcium supplementation ； body composition ； China