An Original Discovery: Selenium Deficiency and Keshan Disease (an Endemic Heart Disease)

Translated Titles





Jun-Shi Chen

Key Words

硒 ; 克山症 ; 轉化研究 ; 必需微量營養素 ; selenium ; Keshan disease ; translational research ; essential trace element


Asia Pacific Journal of Clinical Nutrition

Volume or Term/Year and Month of Publication

21卷3期(2012 / 09 / 01)

Page #

320 - 326

Content Language


Chinese Abstract


English Abstract

This is a review article telling a 50-years old story about the studies on selenium deficiency and Keshan disease in China, an endemic heart disease with high case-fatality, as an example of translational research. Extensive cross-sectional epidemiological studies showed that low selenium concentrations in cereal grains and low selenium status of local residents were associated with the occurrence of Keshan disease. Several large population-based intervention trials using oral administration of sodium selenite tablets showed significant reduction of Keshan disease incidence. Based on the above evidence, it was concluded that selenium deficiency is the major cause of Keshan disease, although other etiological factors could not be ruled out. The implications of the findings include: provided critical scientific evidence for selenium being an essential trace element for humans; as scientific basis for identifying minimum requirement and RDA/RNI for selenium; and as solid reference for the formulation of effective preventive measures for Keshan disease in China.

Topic Category 醫藥衛生 > 預防保健與衛生學
Times Cited
  1. Mark L. Wahlqvist(2014)。Ecosystem Health Disorders-Changing Perspectives in Clinical Medicine and Nutrition。Asia Pacific Journal of Clinical Nutrition。23(1)。1-15。 
  2. Mark L Wahlqvist(2013)。Antioxidant Relevance to Human Health。Asia Pacific Journal of Clinical Nutrition。22(2)。171-176。 
  3. 葉佩沂(2017)。探討肝癌患者血漿硒濃度與抗氧化能力及氧化壓力之關係—先驅性研究。中山醫學大學營養學系碩士班學位論文。2017。1-48。