Randomized, Double-Blind, Placebo-Controlled Trial of Ficus Carica Paste for the Management of Functional Constipation

Hyang-Im Baek ； Ki-Chan Ha ； Hye-Mi Kim ； Eun-Kyung Choi ； Eun-Ock Park ； Byung-Hyun Park ； Hye Jeong Yang ； Min Jung Kim ； Hee Joo Kang ； Soo-Wan Chae

《Asia Pacific Journal of Clinical Nutrition》 預刊文章 Pp. 70-87

https://doi.org/10.6133/apjcn.092015.06

並列摘要

Objectives: Constipation affects up to 20% of the world’s population. The aim of this study was to investigate whether supplementation with 〞Ficus carica〞 paste could be used to treat constipation in Korean subjects with functional constipation. Methods: We conducted a randomized, double-blind, placebo-controlled trial. Subjects with functional constipation were orally supplemented with either 〞F. carica〞 paste (n=40) or placebo (n=40) for 8 weeks. We measured the efficacy and safety of 〞F. carica〞 paste. Primary outcomes (colon transit time) and secondary outcomes (questionnaire related to defecation) were compared before and after the 8-week intervention period. Results: 〞F. carica〞 paste supplementation was associated with a significant reduction in colon transit time and a significant improvement in stool type and abdominal discomfort compared with the placebo. Blood parameters and clinical findings for organ toxicity remained within normal ranges. Conclusion: These results suggest that 〞F. carica〞 paste may have beneficial effects in subjects suffering from constipation.

並列關鍵字

Ficus carica ； constipation ； defecation ； colonic transit time ； clinical trials