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A randomised trial of the feasibility of a low carbohydrate diet vs standard carbohydrate counting in adults with type 1 diabetes taking body weight into account

成人1型糖尿病患者低碳水化合物摄入与标准碳水化合物计数结合体重计数随机试验的可行性

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摘要


背景与目的:在1型糖尿病患者中,与标准碳水化合物计数比较,确定低碳水化合物饮食对血糖控制、血糖波动以及每日胰岛素使用的影响。方法与研究设计:参加二级保健门诊使用普通膳食以注射胰岛素为治疗方案的10例1型糖尿病患者,按照1:1的比例随机分配到一个标准的碳水化合物计数组,或限制碳水化合物饮食组(每天75 g)。测量了所有志愿者基线和12周的体重、身高、血压、糖化血红蛋白、血脂和肌酐,志愿者完成了为期3天的食物日记和3天持续皮下血糖监测。结果:碳水化合物限制组HbA1c(63-55 mmol/mol(8.9-8.2 %),p<0.05)和每日胰岛素用量(64.4-44.2 U/d,p<0.05)显著减少,体重(83.2-78 kg)的变化无显著差异。碳水化合物计数组血压、肌酐或血脂所有指标均无显著改变。通过平均血糖波动幅度计算的血糖变异性在任何一组中均无改变。结论:低碳水化合物饮食是1型糖尿病患者一个可行的选择,可以减少胰岛素剂量和改善血糖控制,特别是对那些希望减肥的患者。

並列摘要


Background and Objectives: To determine the effect of a low carbohydrate diet and standard carbohydrate counting on glycaemic control, glucose excursions and daily insulin use compared with standard carbohydrate counting in participants with type 1 diabetes. Methods and Study Design: Participants (n=10) with type 1 diabetes using a basal; bolus insulin regimen, who attended a secondary care clinic, were randomly allocated (1:1) to either a standard carbohydrate counting course or the same course with added information on following a carbohydrate restricted diet (75 g per day). Participants attended visits at baseline and 12 weeks for measurements of weight, height, blood pressure, HbA1c, lipid profile and creatinine. They also completed a 3-day food diary and had 3 days of continuous subcutaneous glucose monitoring. Results: The carbohydrate restricted group had significant reductions in HbA1c (63 to 55 mmol/mol (8.9-8.2%), p<0.05) and daily insulin use (64.4 to 44.2 units/day, p<0.05) and non-significant reductions in body weight (83.2 to 78.0 kg). There were no changes in blood pressure, creatinine or lipid profile and all outcomes in the carbohydrate counting group were unchanged. There was no change in glycaemic variability as measured by the mean amplitude of glycaemic excursion in either group. Conclusions: A low carbohydrate diet is a feasible option for people with type 1 diabetes, and may be of benefit in reducing insulin doses and improving glycaemic control, particularly for those wishing to lose weight.

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