Vitamin D status of Māori and non-Māori octogenarians in New Zealand: a Cohort Study (LiLACS NZ)

新西兰毛利族和非毛利族八旬老人维生素D状况：一项队列研究

Catherine J Bacon ； Ngaire Kerse ； Karen J Hayman ； Simon A Moyes ； Ruth O Teh ； Mere Kepa ； Avinesh Pillai ； Lorna Dyall

《Asia Pacific Journal of Clinical Nutrition》 25卷4期 (2016/12) Pp. 885-897

https://doi.org/10.6133/apjcn.092015.42

摘要

背景与目的：本研究评估了队列研究中生活在新西兰湾和湖泊区域的八旬老人的维生素D 状况及其决定因素。方法与研究设计：测量209 名毛利人（80-90岁）和357 名非毛利人（85 岁）的血清25-羟维生素D（25(OH)D）的浓度，同时收集研究对象的体格测量指标、生活方式、补充剂的应用和其它健康资料。结果：平均25(OH)D 浓度为69（95% CI : 67-72）nmol/L，其中15%的研究对象＞100 nmol/L，6 个研究对象＞150 nmol/L。毛利人的25(OH)D 浓度（59nmol/L，95% CI: 55-62 nmol/L）低于非毛利人（75 nmol/L，95% CI : 72-78nmol/L，p＜0.001），校正测量日期后，差异仍然存在。98 名（占18%）研究对象报告补充了维生素D，女性中补充者所占的比例（24%）高于男性（11%，p＜0.001），非毛利人中补充者所占的比例高于毛利人。补充维生素D 的人中，49%的人摄入高剂量（每天≥25 μg 或相当剂量），5 个研究对象每天摄入维生素D≥50 μg。维生素D 补充剂的应用能够强而独立地预测季节校正的25(OH)D 浓度，并且使用者比不用者高28 nmol/L。其它预测指标包括毛利族（比非毛利族低10 nmol/L）和女性性别（比男性低11 nmol/L）。结论：新西兰八旬老人维生素D 浓度高于以前的报告，尤其是非毛利人。这个人群中处方和非处方口服维生素D 补充剂普遍存在，并且是维生素状态的强预测指标。

關鍵字

骨化醇 ； 季节变化 ； 民族 ； 年龄在80岁及其以上 ； 老年人

並列摘要

Background and Objectives: This study assessed vitamin D status and its determinants in a cohort of octogenarians living within New Zealand's Bay of Plenty and Lakes Districts. Methods and Study Design: Serum 25- hydroxyvitamin D [25(OH)D] concentration was measured in 209 Māori (aged 80-90 years) and 357 non-Māori (85 years), along with demographic, lifestyle, supplement use and other health data. Results: Mean [95% CI] 25(OH)D concentration was 69 [67 to 72] nmol/L, with 15% ＞100 nmol/L and 6 individuals ＞150 nmol/L. Concentrations in Māori (59 [55 to 62] 4 nmol/L) were lower than in non-Māori (75 [72 to 78] nmol/L; p＜0.001), a difference maintained when adjusted for day-of-year measured. Vitamin D supplementation was reported by 98 participants (18%): including a greater proportion of women (24%) than men (11%; p＜0.001) and of non-Māori (24%) than Māori (7%; p＜0.001). Of those taking vitamin D, 49% took high oral doses (≥25 μg/day or equivalent) and five individuals took ＞50 μg/day. Vitamin D supplement use strongly and independently predicted seasonally- adjusted 25(OH)D concentration and was associated with 28 nmol/L higher levels than non-use. Other predictors included Māori ethnicity (10 nmol/L lower concentration than for non-Māori), and female gender (11 nmol/L lower). Conclusions: Vitamin D status in New Zealand octogenarians appears higher than previously reported, particularly in non-Māori compared to Māori. Prescribed and non-prescribed oral vitamin D supplementation is prevalent in this group and a strong indicator of vitamin D status.

並列關鍵字

calciferol ； seasonal variation ； ethnic groups ； aged 80 and over ； elderly